Orthodontic tooth separation activates the hypothalamic area in the human brain.
10.1038/s41368-017-0001-y
- Author:
Yoshiko ARIJI
1
;
Hisataka KONDO
2
;
Ken MIYAZAWA
3
;
Masako TABUCHI
3
;
Syuji KOYAMA
4
;
Yoshitaka KISE
5
;
Akifumi TOGARI
2
;
Shigemi GOTOH
3
;
Eiichiro ARIJI
5
Author Information
1. Department of Oral and Maxillofacial Radiology, Aichi-Gakuin University School of Dentistry, Nagoya, Japan. yoshiko@dpc.agu.ac.jp.
2. Department of Pharmacology, Aichi-Gakuin University School of Dentistry, Nagoya, Japan.
3. Department of Orthodontics, Aichi-Gakuin University School of Dentistry, Nagoya, Japan.
4. Brain and Mind Research Center, Nagoya University, Nagoya, Japan.
5. Department of Oral and Maxillofacial Radiology, Aichi-Gakuin University School of Dentistry, Nagoya, Japan.
- Publication Type:Journal Article
- MeSH:
Brain Mapping;
methods;
Healthy Volunteers;
Humans;
Hypothalamus;
diagnostic imaging;
Magnetic Resonance Imaging;
methods;
Medulla Oblongata;
diagnostic imaging;
Tooth Movement Techniques;
instrumentation
- From:
International Journal of Oral Science
2018;10(2):8-8
- CountryChina
- Language:English
-
Abstract:
OBJECTIVES:An animal experiment clarified that insertion of an orthodontic apparatus activated the trigeminal neurons of the medulla oblongata. Orthodontic tooth movement is known to be associated with the sympathetic nervous system and controlled by the nucleus of the hypothalamus. However, the transmission of both has not been demonstrated in humans. The purpose of this study were to examine the activated cerebral areas using brain functional magnetic resonance imaging (MRI), when orthodontic tooth separators were inserted, and to confirm the possibility of the transmission route from the medulla oblongata to the hypothalamus.
METHODS:Two types of alternative orthodontic tooth separators (brass contact gauge and floss) were inserted into the right upper premolars of 10 healthy volunteers. Brain functional T2*-weighted images and anatomical T1-weighted images were taken.
RESULTS:The blood oxygenation level dependent (BOLD) signals following insertion of a brass contact gauge and floss significantly increased in the somatosensory association cortex and hypothalamic area.
CONCLUSION:Our findings suggest the possibility of a transmission route from the medulla oblongata to the hypothalamus.
