Accelerated and enhanced osteointegration of MAO-treated implants: histological and histomorphometric evaluation in a rabbit model.
10.1038/s41368-018-0008-z
- Author:
Xin LI
1
;
Haiyang XU
2
;
Baodong ZHAO
3
;
Shuai JIANG
4
Author Information
1. Department of Oral Implantology, the Affiliated Hospital of Qingdao University, Qingdao, China.
2. Department of Oral Implantology of Zibo Central Hospital, Zibo, China.
3. Department of Oral Implantology, the Affiliated Hospital of Qingdao University, Qingdao, China. zbd315@sina.com.
4. School of Stomatology, Qingdao University, Qingdao, China.
- Publication Type:Journal Article
- MeSH:
Animals;
Bone-Implant Interface;
physiology;
Dental Implantation, Endosseous;
methods;
Dental Implants;
Femur;
surgery;
Implants, Experimental;
Materials Testing;
Microscopy, Confocal;
Microscopy, Electron, Scanning;
Microscopy, Fluorescence;
Models, Animal;
Osseointegration;
physiology;
Oxidation-Reduction;
Rabbits;
Spectrometry, X-Ray Emission;
Surface Properties;
Titanium
- From:
International Journal of Oral Science
2018;10(2):11-11
- CountryChina
- Language:English
-
Abstract:
Microarc oxidation (MAO) has become a promising technique for the surface modification of implants. Therefore, the aims of this study were to further quantitatively and qualitatively evaluate the osteointegration abilities of MAO-treated and smooth surface (SF) implants in vivo and to investigate the areas in which the superiority of MAO-treated implants are displayed. In a rabbit model, a comprehensive histomorphological, osteogenic, mineralizational, and integrative assessment was performed using light microscopy, fluorescence microscopy, confocal laser scanning microscopy, and radiographic analyses. Compared with the SF groups, the MAO-treated groups exhibited more active contact osteogenesis, as well as distant osteogenesis, under fluorescence examination, the mineral apposition rate was found to be greater for all of the MAO-treated implants, and the osteointegration index (OI) value was greater in the MAO-treated groups at different times. In conclusion, the calcium-rich amorphous layer created by MAO provided a better environment for osteointegration, with more active contact osteogenesis, a more rapid mineral apposition rate and greater OI values.
