Effects of water-aging for 6 months on the durability of a novel antimicrobial and protein-repellent dental bonding agent.
10.1038/s41368-018-0019-9
- Author:
Ning ZHANG
1
;
Ke ZHANG
2
;
Michael D WEIR
3
;
David J XU
3
;
Mark A REYNOLDS
3
;
Yuxing BAI
4
;
Hockin H K XU
5
Author Information
1. Department of Orthodontics, School of Stomatology, Capital Medical University, Beijing, China.
2. Department of Orthodontics, School of Stomatology, Capital Medical University, Beijing, China. tuzizhangke@163.com.
3. Biomatexrials & Tissue Engineering Division, Department of Endodontics, Periodontics and Prosthodontics, University of Maryland Dental School, Baltimore, MD, USA.
4. Department of Orthodontics, School of Stomatology, Capital Medical University, Beijing, China. byuxing@263.net.
5. Biomatexrials & Tissue Engineering Division, Department of Endodontics, Periodontics and Prosthodontics, University of Maryland Dental School, Baltimore, MD, USA. hxu@umaryland.edu.
- Publication Type:Journal Article
- MeSH:
Anti-Infective Agents;
chemistry;
pharmacology;
Biofilms;
drug effects;
Dental Bonding;
Dentin-Bonding Agents;
chemistry;
pharmacology;
Materials Testing;
Methacrylates;
chemistry;
pharmacology;
Phosphorylcholine;
analogs & derivatives;
chemistry;
pharmacology;
Resin Cements;
Shear Strength;
Surface Properties;
Water
- From:
International Journal of Oral Science
2018;10(2):18-18
- CountryChina
- Language:English
-
Abstract:
Biofilms at the tooth-restoration bonded interface can produce acids and cause recurrent caries. Recurrent caries is a primary reason for restoration failures. The objectives of this study were to synthesize a novel bioactive dental bonding agent containing dimethylaminohexadecyl methacrylate (DMAHDM) and 2-methacryloyloxyethyl phosphorylcholine (MPC) to inhibit biofilm formation at the tooth-restoration margin and to investigate the effects of water-aging for 6 months on the dentin bond strength and protein-repellent and antibacterial durability. A protein-repellent agent (MPC) and antibacterial agent (DMAHDM) were added to a Scotchbond multi-purpose (SBMP) primer and adhesive. Specimens were stored in water at 37 °C for 1, 30, 90, or 180 days (d). At the end of each time period, the dentin bond strength and protein-repellent and antibacterial properties were evaluated. Protein attachment onto resin specimens was measured by the micro-bicinchoninic acid approach. A dental plaque microcosm biofilm model was used to test the biofilm response. The SBMP + MPC + DMAHDM group showed no decline in dentin bond strength after water-aging for 6 months, which was significantly higher than that of the control (P < 0.05). The SBMP + MPC + DMAHDM group had protein adhesion that was only 1/20 of that of the SBMP control (P < 0.05). Incorporation of MPC and DMAHDM into SBMP provided a synergistic effect on biofilm reduction. The antibacterial effect and resistance to protein adsorption exhibited no decrease from 1 to 180 d (P > 0.1). In conclusion, a bonding agent with MPC and DMAHDM achieved a durable dentin bond strength and long-term resistance to proteins and oral bacteria. The novel dental bonding agent is promising for applications in preventive and restorative dentistry to reduce biofilm formation at the tooth-restoration margin.
