Photodynamic therapy guidelines for the management of oral leucoplakia.
10.1038/s41368-019-0047-0
- Author:
Qianming CHEN
1
;
Hongxia DAN
1
;
Fan TANG
1
;
Jiongke WANG
1
;
Xiaoying LI
1
;
Junxin CHENG
1
;
Hang ZHAO
2
;
Xin ZENG
3
Author Information
1. State Key Laboratory of Oral Diseases, National Clinical Research Center for Oral Diseases, Chinese Academy of Medical Sciences Research Unit of Oral Carcinogenesis and Management, West China Hospital of Stomatology, Sichuan University, 610041, Chengdu, Sichuan, China.
2. State Key Laboratory of Oral Diseases, National Clinical Research Center for Oral Diseases, Chinese Academy of Medical Sciences Research Unit of Oral Carcinogenesis and Management, West China Hospital of Stomatology, Sichuan University, 610041, Chengdu, Sichuan, China. zhaohangahy@scu.edu.cn.
3. State Key Laboratory of Oral Diseases, National Clinical Research Center for Oral Diseases, Chinese Academy of Medical Sciences Research Unit of Oral Carcinogenesis and Management, West China Hospital of Stomatology, Sichuan University, 610041, Chengdu, Sichuan, China. zengxin22@163.com.
- Publication Type:Journal Article
- MeSH:
Aminolevulinic Acid;
administration & dosage;
therapeutic use;
Humans;
Leukoplakia, Oral;
therapy;
Photochemotherapy;
methods;
Photosensitizing Agents;
administration & dosage;
therapeutic use;
Practice Guidelines as Topic
- From:
International Journal of Oral Science
2019;11(2):14-14
- CountryChina
- Language:English
-
Abstract:
With recent developments in photosensitizers and light delivery systems, topical 5-aminolevulinic acid-mediated photodynamic therapy (ALA-PDT) has become the fourth alternative therapeutic approach in the management of oral leucoplakia (OLK) due to its minimally invasive nature, efficacy, and low risk of systemic side effects and disfigurement. This report presents step-by-step guidelines for applying topical ALA-PDT in the management of OLK based on both the clinical experience of the authors and a systematic review of the current literature. Studies using protocols with standardized parameters and randomized clinical trials at multiple centres with adequate sample sizes and both interim and long-term follow-ups are needed before universally applicable guidelines can be produced in this field.
