Recent advances in cell sheet technology for bone and cartilage regeneration: from preparation to application.
10.1038/s41368-019-0050-5
- Author:
Yuezhi LU
1
,
2
,
3
,
4
;
Wenjie ZHANG
1
,
2
,
3
,
4
;
Jie WANG
1
,
2
,
3
,
4
;
Guangzheng YANG
1
,
2
,
3
,
4
;
Shi YIN
1
,
2
,
3
,
4
;
Tingting TANG
5
;
Chunhua YU
1
,
2
,
3
,
6
;
Xinquan JIANG
1
,
2
,
3
,
7
Author Information
1. Department of Prosthodontics, Shanghai Ninth People's Hospital, College of Stomatology, Shanghai Jiao Tong University School of Medicine
2. National Clinical Research Center for Oral Diseases
3. Shanghai Engineering Research Center of Advanced Dental Technology and Materials
4. Shanghai Key Laboratory of Stomatology & Shanghai Research Institute of Stomatology, Shanghai, China.
5. Shanghai Key Laboratory of Orthopaedic Implants, Department of Orthopaedic Surgery, Shanghai Ninth People's Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China.
6. Shanghai Key Laboratory of Stomatology & Shanghai Research Institute of Stomatology, Shanghai, China. yuchunhua656663@163.com.
7. Shanghai Key Laboratory of Stomatology & Shanghai Research Institute of Stomatology, Shanghai, China. xinquanj@aliyun.com.
- Publication Type:Journal Article
- MeSH:
Bone Regeneration;
Bone and Bones;
Cartilage, Articular;
Regeneration;
Tissue Engineering;
trends;
Tissue Scaffolds
- From:
International Journal of Oral Science
2019;11(2):17-17
- CountryChina
- Language:English
-
Abstract:
Bone defects caused by trauma, tumour resection, infection and congenital deformities, together with articular cartilage defects and cartilage-subchondral bone complex defects caused by trauma and degenerative diseases, remain great challenges for clinicians. Novel strategies utilising cell sheet technology to enhance bone and cartilage regeneration are being developed. The cell sheet technology has shown great clinical potential in regenerative medicine due to its effective preservation of cell-cell connections and extracellular matrix and its scaffold-free nature. This review will first introduce several widely used cell sheet preparation systems, including traditional approaches and recent improvements, as well as their advantages and shortcomings. Recent advances in utilising cell sheet technology to regenerate bone or cartilage defects and bone-cartilage complex defects will be reviewed. The key challenges and future research directions for the application of cell sheet technology in bone and cartilage regeneration will also be discussed.
