The cytokine network involved in the host immune response to periodontitis.
10.1038/s41368-019-0064-z
- Author:
Weiyi PAN
1
;
Qingxuan WANG
1
;
Qianming CHEN
2
Author Information
1. State Key Laboratory of Oral Diseases & National Clinical Research Center for Oral Diseases & Chinese Academy of Medical Sciences Research Unit of Oral Carcinogenesis and Management, West China Hospital of Stomatology, Sichuan University, Chengdu, China.
2. State Key Laboratory of Oral Diseases & National Clinical Research Center for Oral Diseases & Chinese Academy of Medical Sciences Research Unit of Oral Carcinogenesis and Management, West China Hospital of Stomatology, Sichuan University, Chengdu, China. qmchen@scu.edu.cn.
- Publication Type:Journal Article
- MeSH:
Alveolar Bone Loss;
etiology;
Cytokines;
metabolism;
physiology;
Humans;
Inflammation;
Periodontal Diseases;
Periodontitis;
immunology;
microbiology;
Tumor Necrosis Factor-alpha;
physiology
- From:
International Journal of Oral Science
2019;11(3):30-30
- CountryChina
- Language:English
-
Abstract:
Periodontitis is an inflammatory disease involving the destruction of both soft and hard tissue in the periodontal region. Although dysbiosis of the local microbial community initiates local inflammation, over-activation of the host immune response directly activates osteoclastic activity and alveolar bone loss. Many studies have reported on the cytokine network involved in periodontitis and its crucial and pleiotropic effect on the recruitment of specific immunocytes, control of pathobionts and induction or suppression of osteoclastic activity. Nonetheless, particularities in the stimulation of pathogens in the oral cavity that lead to the specific and complex periodontal cytokine network are far from clarified. Thus, in this review, we begin with an up-to-date aetiological hypothesis of periodontal disease and summarize the roles of cytokines in the host immune response. In addition, we also summarize the latest cytokine-related therapeutic measures for periodontal disease.
