Association of CDKN2B-AS1 Polymorphisms with Premature Triple-vessel Coronary Disease and Their Sex Specificity in the Chinese Population.

Jing Jing XU; Lin Jiang; Lian Jun XU; Zhan Gao; Xue Yan Zhao; Yin Zhang; Ying Song; Ru Liu; Kai Sun; Run Lin Gao; Bo XU; Lei Song; Jin Qing Yuan

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Association of CDKN2B-AS1 Polymorphisms with Premature Triple-vessel Coronary Disease and Their Sex Specificity in the Chinese Population.

Author: Jing Jing XU ¹ ; Lin JIANG ¹ ; Lian Jun XU ¹ ; Zhan GAO ¹ ; Xue Yan ZHAO ¹ ; Yin ZHANG ² ; Ying SONG ¹ ; Ru LIU ¹ ; Kai SUN ³ ; Run Lin GAO ¹ ; Bo XU ¹ ; Lei SONG ^{4
,

5} ; Jin Qing YUAN ¹
Author Information

1. Department of cardiology, Fuwai Hospital, National Center for Cardiovascular Diseases, Chinese Academy of Medical Science and Peking Union Medical College, Beijing 100037, China.
2. Department of cardiology, Fuwai Hospital, National Center for Cardiovascular Diseases, Chinese Academy of Medical Science and Peking Union Medical College, Beijing 100037, ChinaGuangxi Zhuang Autonomous Region Center for Disease Prevention and Control, Nanning 530028, Guangxi, China.
3. State Key Laboratory of Cardiovascular Disease, Fuwai Hospital, National Center for Cardiovascular Diseases, Chinese Academy of Medical Science and Peking Union Medical College, Beijing 100037, China.
4. State Key Laboratory of Cardiovascular Disease, Fuwai Hospital, National Center for Cardiovascular Diseases, Chinese Academy of Medical Science and Peking Union Medical College, Beijing 100037, China
5. Department of Hypertension, Fuwai Hospital, National Center for Cardiovascular Diseases, Chinese Academy of Medical Science and Peking Union Medical College, Beijing 100037, China.
Publication Type:Clinical Trial
Keywords: Premature triple-vessel disease; Risk; Single-nucleotide polymorphism
MeSH: Adult; Asian Continental Ancestry Group; genetics; China; Coronary Artery Disease; genetics; Cyclin-Dependent Kinase Inhibitor p15; genetics; Female; Gene Frequency; Genetic Predisposition to Disease; Humans; Male; Middle Aged; Polymorphism, Single Nucleotide; RNA, Antisense; genetics; Sex Factors
From: Biomedical and Environmental Sciences 2018;31(11):787-796
CountryChina
Language:English
Abstract: OBJECTIVE:The aim of this study is to establish whether cyclin-dependent kinase inhibitor 2B antisense RNA 1 (CDKN2B-AS1) gene polymorphisms are associated with premature triple-vessel disease (PTVD).
METHODS:Nine single-nucleotide polymorphisms (rs1063192, rs10757274, rs1333042, rs1333049, rs2285327, rs3217986, rs3217992, rs4977574, and rs9632884) were genotyped in 884 PTVD patients and 907 control subjects (males ⪕ 50 years old and females ⪕ 60 years old) using the improved multiplex ligase detection reaction method.
RESULTS:The allele frequencies of rs10757274 G, rs1333049 C, rs4977574 G (all P < 0.001), and rs3217986 G (P = 0.040) were significantly higher in the PTVD group than in the control group, but those of rs1063192 A, rs1333042 G, and rs9632884 C (all P < 0.001) were significantly lower in the former than in the latter. Logistic regression analysis revealed that homozygote AA of rs1333042 is associated with decreased risk for PTVD (OR = 0.42, 95% CI: 0.22-0.82, P = 0.011). In addition, the allele frequencies observed differed between genders. The G allele of rs3217986 was associated with increased risk for PTVD in male patients only (OR = 2.94, 95% CI: 1.27-6.80, P = 0.012) in the dominant model, and no positively mutated allele was found in female patients.
CONCLUSION:Polymorphisms of the CDKN2B-AS1 gene are associated with the incidence of PTVD in the Chinese population. Furthermore, the frequencies of mutated alleles differed between genders.