Exposure to Radon and Kidney Cancer: A Systematic Review and Meta-analysis of Observational Epidemiological Studies.

Bin Chen; Tan Wei Yuan; Ai Qing Wang; Hong Zhang; Li Jun Fang; Qian Qian WU; Hong Bo Zhang; Sha Sha Tao; Hai Lin Tian

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Exposure to Radon and Kidney Cancer: A Systematic Review and Meta-analysis of Observational Epidemiological Studies.

Author: Bin CHEN ^{1
,

2} ; Tan Wei YUAN ³ ; Ai Qing WANG ^{1
,

4} ; Hong ZHANG ³ ; Li Jun FANG ³ ; Qian Qian WU ³ ; Hong Bo ZHANG ⁵ ; Sha Sha TAO ^{1
,

6} ; Hai Lin TIAN ^{1
,

6}
Author Information

1. School of Public Health, Medical College of Soochow University, Suzhou 215123, Jiangsu, China
2. Suzhou Gusu District Center For Disease Prevention and Control, Suzhou 215123, Jiangsu, China.
3. School of Public Health, Medical College of Soochow University, Suzhou 215123, Jiangsu, China.
4. Experimental Center of Medical College, Soochow University, Suzhou 215123, Jiangsu, China.
5. Suzhou Xiangcheng District For Maternal and Child Care Service Centre, Suzhou 215123, Jiangsu, China.
6. Jiangsu Key Laboratory of Preventive and Translational Medicine for Geriatric Diseases, School of Public Health, Soochow University, Suzhou 215123, Jiangsu, China.
Publication Type:Journal Article
Keywords: Kidney; Meta-analysis; Radon; Systematic review
MeSH: Cohort Studies; Environmental Exposure; adverse effects; Humans; Kidney Neoplasms; etiology; Radon; toxicity
From: Biomedical and Environmental Sciences 2018;31(11):805-815
CountryChina
Language:English
Abstract: OBJECTIVE:To evaluate the possible association between radon exposure and kidney cancer.
METHODS:We performed a systematic review and a meta-analysis based on random effect models to provide a pooled association measure.
RESULTS:We subjected 8 studies (overall relative risks and 95% confidence intervals: 1.01, 0.72 to 1.43, I2 = 64.4%) to meta-analysis. Subgroup analysis revealed a marginally significant association between radon exposure and kidney cancer in studies conducted in Europe. Two population-based studies provided no evidence for the increased risk of kidney cancer in the general population.
CONCLUSION:The association between radon and kidney cancer remains unclear but cannot be excluded because of its biological plausibility and the limited number and quality of existing studies. Additional data from the general population and well-designed miner cohort studies are needed to reveal the real relationship between radon exposure and kidney cancer.