De Novo AL Amyloidosis in a Renal Allograft.
10.3904/kjm.2016.90.6.545
- Author:
Ji Yeon HWANG
1
;
Dong Ryeol LEE
;
Jung Myung AN
;
Sung Jun KIM
;
Dong Kyu KIM
;
Min Gi PARK
;
Su Ho PARK
Author Information
1. Department of Internal Medicine, Maryknoll Hospital, Busan, Korea. egis70@naver.com
- Publication Type:Case Report
- Keywords:
De novo AL amyloidosis;
Kidney allograft;
Kidney biopsy;
Immunoglobulin light chains
- MeSH:
Allografts*;
Amyloid;
Amyloidosis*;
Biopsy;
Dyspnea;
Electrophoresis;
Heart;
Humans;
Immunoglobulin Light Chains;
Incidence;
Kidney;
Kidney Transplantation;
Proteinuria;
Transplant Recipients
- From:Korean Journal of Medicine
2016;90(6):545-549
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
Amyloidosis is characterized by the extracellular deposition of amyloid in various tissues and organs, particularly the kidney and heart. The estimated incidence of systemic amyloidosis is at least 8 per million population per year. However, few cases of systemic amyloidosis in renal allografts have been reported. A stable renal transplant recipient was admitted with proteinuria and dyspnea on exertion. The M-peak was found on serum and urine protein electrophoresis, and lambda (λ) dominance was confirmed by serum and urine free-light-chain test. The patient was diagnosed with systemic amyloidosis of a renal allograft, by allograft biopsy, at 22 years after renal transplantation. We report a case of AL amyloidosis in a stable renal allograft and review the medical literature.
