Efficacy of weight adjusted bone mineral content in osteoporosis diagnosis in Chinese female population.
10.1097/CM9.0000000000000143
- Author:
Ting-Ting LIU
1
;
Xiao-Dan LI
2
;
Wen-Zhi WANG
1
;
Jian-Gao ZHANG
3
;
Ding-Zhuo YANG
1
Author Information
1. Department of Internal Medicine, No. 4 West China Teaching Hospital, Sichuan University, Chengdu, Sichuan 610041, China.
2. Department of Internal Medicine, West China Hospital, Sichuan University, Chengdu, Sichuan 610041, China.
3. Faculty of Construction Management and Real Estate, Chongqing University, Chongqing 400045, China.
- Publication Type:Journal Article
- MeSH:
Absorptiometry, Photon;
Adult;
Age Factors;
Body Weight;
physiology;
Bone Density;
physiology;
Female;
Femur Neck;
diagnostic imaging;
metabolism;
Humans;
Lumbar Vertebrae;
diagnostic imaging;
metabolism;
Middle Aged;
Osteoporosis;
diagnostic imaging;
metabolism;
Prevalence;
Young Adult
- From:
Chinese Medical Journal
2019;132(7):772-781
- CountryChina
- Language:English
-
Abstract:
BACKGROUND:Areal bone mineral density (aBMD) applied for osteoporosis diagnosis unavoidably results in the missingdiagnosis in patients with large bones and misdiagnosis in those with small bones. Therefore, we try to find a new adjusted index of bone mineral content (BMC) to make up shortcomings of aBMD in osteoporosis diagnosis.
METHODS:In this multi-center epidemiological study, BMC and aBMD of lumbar spines (n = 5510) and proximal femurs (n = 4710) were measured with dual energy X-ray absorptiometry (DXA). We analyzed the correlation between the bone mass and body weight in all subjects including four age groups (<19 years, 20-39 years, 40-49 years, >50 years). And then the body weight was used for standardizing BMC (named wBMC) and applied for the epidemiological analysis of osteoporosis.
RESULTS:The correlation of body weight and BMC is 0.839 to 0.931 of lumbar vertebra 1-4 (L1-4), and 0.71 to 0.95 of femoral neck in different age groups. When aBMD was applied for diagnosing osteoporosis, the prevalence was 7.55%, 16.39%, and 25.83% in patients with a high, intermediate, and low body weight respectively. However, the prevalence was 21.8%, 18.03%, and 11.64% by wBMC applied for diagnosing osteoporosis. Moreover, the prevalence of osteoporosis increased by 3.76% by wBMC with the body weight increased by 5 kg. The prevalence decreased by 1.94% when the body weight decreased by 5 kg.
CONCLUSIONS:wBMC can reduce the missed diagnosis in patients with large body weight and reduce misdiagnosis in those with small body weight. Including children, wBMC may be feasible for osteoporosis diagnosis individuals at any age.
