Visual-spatial neglect after right-hemisphere stroke: behavioral and electrophysiological evidence.
10.1097/CM9.0000000000000218
- Author:
Lin-Lin YE
1
;
Lei CAO
;
Huan-Xin XIE
;
Gui-Xiang SHAN
;
Yan-Ming ZHANG
;
Wei-Qun SONG
Author Information
1. Department of Rehabilitation, Xuanwu Hospital, Capital Medical University, Beijing 100053, China.
- Publication Type:Journal Article
- MeSH:
Adult;
Aged;
Cerebral Infarction;
physiopathology;
Electrophysiology;
Female;
Humans;
Male;
Middle Aged;
Neuropsychological Tests;
Nitric Oxide Synthase Type III;
genetics;
PPAR gamma;
genetics;
Perceptual Disorders;
genetics;
metabolism;
physiopathology;
Polymorphism, Genetic;
genetics;
Reaction Time;
genetics;
physiology;
Reactive Oxygen Species;
metabolism;
Stroke;
genetics;
metabolism;
physiopathology;
Superoxide Dismutase;
genetics
- From:
Chinese Medical Journal
2019;132(9):1063-1070
- CountryChina
- Language:English
-
Abstract:
BACKGROUND:Visual-spatial neglect (VSN) is a neuropsychological syndrome, and right-hemisphere stroke is the most common cause. The pathogenetic mechanism of VSN remains unclear. This study aimed to investigate the behavioral and event-related potential (ERP) changes in patients with or without VSN after right-hemisphere stroke.
METHODS:Eleven patients with VSN with right-hemisphere stroke (VSN group) and 11 patients with non-VSN with right-hemisphere stroke (non-VSN group) were recruited along with one control group of 11 age- and gender-matched healthy participants. The visual-spatial function was evaluated using behavioral tests, and ERP examinations were performed.
RESULTS:The response times in the VSN and non-VSN groups were both prolonged compared with those of normal controls (P < 0.001). In response to either valid or invalid cues in the left side, the accuracy in the VSN group was lower than that in the non-VSN group (P < 0.001), and the accuracy in the non-VSN group was lower than that in controls (P < 0.05). The P1 latency in the VSN group was significantly longer than that in the control group (F[2, 30] = 5.494, P = 0.009), and the N1 amplitude in the VSN group was significantly lower than that in the control group (F[2, 30] = 4.343, P = 0.022). When responding to right targets, the left-hemisphere P300 amplitude in the VSN group was significantly lower than that in the control group (F[2, 30] = 4.255, P = 0.025). With either left or right stimuli, the bilateral-hemisphere P300 latencies in the VSN and non-VSN groups were both significantly prolonged (all P < 0.05), while the P300 latency did not differ significantly between the VSN and non-VSN groups (all P > 0.05).
CONCLUSIONS:Visual-spatial attention function is impaired after right-hemisphere stroke, and clinicians should be aware of the subclinical VSN. Our findings provide neuroelectrophysiological evidence for the lateralization of VSN.
