Progress in the research of negative feedback effect of thyroglobulin.
10.12122/j.issn.1673-4254.2019.01.20
- Author:
Fei CHEN
1
;
Hongjuan WANG
1
;
Qiang LI
1
;
Zhichao LI
1
;
Yuqian LUO
2
Author Information
1. Department of Thyroid Surgery, Zhujiang Hospital, Southern Medical University, Guangzhou 510280, China.
2. Department of Laboratory Medicine, Jiangsu Key Laboratory for Molecular Medicine, Nanjing University Medical School, Nanjing 210008, China.
- Publication Type:Journal Article
- Keywords:
follicular cycle model;
negative feedback effect;
thyroglobulin;
thyroid hormone synthesis
- MeSH:
Feedback, Physiological;
Humans;
Hypothalamo-Hypophyseal System;
physiology;
Neoplasm Recurrence, Local;
Thyroglobulin;
metabolism;
Thyroid Gland;
physiology;
Thyroid Hormones;
metabolism;
Thyrotropin;
metabolism
- From:
Journal of Southern Medical University
2019;39(1):125-126
- CountryChina
- Language:Chinese
-
Abstract:
Thyroglobulin is the most important and abundant protein in thyroid follicles and has been widely studied as a tumor marker of thyroid cancer recurrence and persistence. Tg is considered the material basis of thyroid hormone synthesis and does not participate in the regulation of thyroid hormone synthesis and secretion. This review summarizes the recent progress in the research of thyroid hormone synthesis and secretion regulation via a negative feedback regulation mechanism by the thyroid-hypothalamus-pituitary axis. Thyroglobulin can negatively regulate the synthesis of thyroid hormone by thyroid follicular cells and antagonize the positive regulation of thyrotropin TSH. The function of thyroid follicular cells is presumably a result of Tg and TSH interaction, and a follicular cycle model is proposed to explain the causes of follicular heterogeneity in glands. We also discuss the prospects and clinical significance of studies into the negative feedback regulation mechanism of the thyroid-hypothalamus-pituitary axis and compare two theories for this mechanism.
