Structure and function of B-cell linker and its role in the development of B cell-related diseases.
10.12122/j.issn.1673-4254.2019.02.20
- Author:
Bin XIAO
1
;
Jiaying LI
2
;
Mengsi ZHOU
2
;
Xiaoqing LI
1
;
Xiaoyan HUANG
1
;
Jianfeng HANG
1
;
Zhaohui SUN
1
;
Linhai LI
1
Author Information
1. Department of Laboratory Medicine, General Hospital of Southern Theatre Command of PLA, Guangzhou 510010, China.
2. Department of Clinical Laboratory, Nanfang Hospital, Southern Medical University, Guangzhou 510515, China.
- Publication Type:Journal Article
- Keywords:
B cell receptor;
B cell-related diseases;
B-cell linker;
differentiation;
signaling pathway
- MeSH:
Adaptor Proteins, Signal Transducing;
chemistry;
genetics;
physiology;
Apoptosis;
B-Lymphocytes;
cytology;
physiology;
Cell Differentiation;
Cell Proliferation;
Humans;
Mutation;
Receptors, Antigen, B-Cell;
chemistry;
physiology;
Signal Transduction;
Structure-Activity Relationship
- From:
Journal of Southern Medical University
2019;39(2):253-256
- CountryChina
- Language:Chinese
-
Abstract:
B cell linker (BLNK) is a key linker protein of B cell receptor (BCR) signaling pathway. BLNK participates in the regulation of PLC-γactivity and the activation of Ras pathway through its typical structure and interaction network with other proteins, and is thus widely involved in the regulation of B cell proliferation, differentiation, apoptosis and signal transduction. Furthermore, it is closely related to anaphylactic diseases, multiple sclerosis, chromosomal aneuploidy, aneuglobulinemia, B lymphocytic leukemia and lymphoma. Herein we review the structure and biological function of BLNK and its role in B cell-related diseases. BLNK can cooperate with a series of effective proteins to activate BCR signaling pathway, thereby regulating the development, maturation and function of B cells. The functional mutation of BLNK can destroy the homeostasis of B cells and affect the development and maturation of B cells, which leads to the occurrence of B cell related diseases. A comprehensive understanding of the biological functions of BLNK not only provides insights into the pathogenesis of B cell-related diseases, but also inspires new ideas and helps to find breakthroughs for the treatment of these diseases with BLNK as the therapeutic target.
