Diagnostic Value of Specific IgE to Peanut and Ara h 2 in Korean Children with Peanut Allergy.
10.4168/aair.2016.8.2.156
- Author:
Hye Young KIM
1
;
Youngshin HAN
;
Kwanghoon KIM
;
Ji Young LEE
;
Min Ji KIM
;
Kangmo AHN
;
Jihyun KIM
Author Information
1. Department of Pediatrics, Medical Research Institute of Pusan National University Hospital, Pusan National University School of Medicine, Busan, Korea.
- Publication Type:Original Article
- Keywords:
Food allergy;
peanut allergy;
specific IgE
- MeSH:
Anaphylaxis;
Antibodies;
Child*;
Diagnosis;
Food Hypersensitivity;
Humans;
Immunoglobulin E*;
Peanut Hypersensitivity*;
ROC Curve;
Sensitivity and Specificity
- From:Allergy, Asthma & Immunology Research
2016;8(2):156-160
- CountryRepublic of Korea
- Language:English
-
Abstract:
PURPOSE: The purpose of this study was to establish the diagnostic decision point (DDP) of peanut specific IgE (sIgE) for predicting the outcome of oral food challenge (OFC). We also evaluated the usefulness of sIgE to peanut components (Ara h 1, 2, 3, 8, and 9) in diagnosing peanut allergy. METHODS: Korean children aged over 12 months with a suspected peanut allergy were enrolled. Diagnosis of peanut allergy was confirmed by an open OFC or through the convincing history of anaphylaxis. Cutoff levels of sIgE to peanut and peanut components were determined by analyzing receiver operating characteristic curves. RESULTS: Forty-eight children (22 boys and 26 girls) with a suspected peanut allergy were enrolled. The previously established DDP for peanut-sIgE antibodies (14 kU/L) showed a sensitivity of 22.7%, specificity of 100%, positive predictive value (PPV) of 100%, and negative predictive value of 60.4% in our study population. The median levels of peanut-sIgE (5.4 kU/L vs 1.1 kU/L, P<0.001) and Ara h 2-sIgE (0.8 kU/L vs 0 kU/L, P<0.001) were significantly higher in the peanut allergy group than in the peanut tolerance group. The peanut-sIgE concentration indicating a PPV of 100% was 10.3 kU/L. The Ara h 2-sIgE level of 4.0 kU/L had a PPV of 100%. CONCLUSIONS: Our results showed that the cutoff levels for peanut (10.3 kU/L) and Ara h 2 (4.0 kU/L) established in this study is useful for the diagnosis of peanut allergy in Korean children.
