Research progress of exosomes in epithelial-mesenchymal transition.
10.12122/j.issn.1673-4254.2019.03.19
- Author:
Jingyu QUAN
1
;
Zibin LU
1
;
Linzhong YU
1
;
Chunlin FAN
2
;
Huihui CAO
1
;
Junshan LIU
1
Author Information
1. School of Traditional Chinese Medicine, Southern Medical University, Guangzhou 510515, China.
2. College of Pharmacy, Jinan University, Guangzhou 510632, China.
- Publication Type:Journal Article
- Keywords:
epithelial-mesenchymal transition;
exosomes;
fibrosis;
tumor
- MeSH:
Epithelial-Mesenchymal Transition;
Exosomes;
Humans;
MicroRNAs;
Neoplasms;
Signal Transduction
- From:
Journal of Southern Medical University
2019;39(3):377-380
- CountryChina
- Language:Chinese
-
Abstract:
Exosome, a membranous vesicle with biological activity, not only transmits active substances between cells but also transfers information between cells to participate in cell communication. Epithelial-mesenchymal transition (EMT) is a process by which epithelial cells acquire migratory and invasive properties to become mesenchymal stem cells. EMT is essential for the development of a spectrum of diseases. Studies have shown that exosomes have dual effects on EMT to, on the one hand, promote EMT and tumor cell invasion and metastasis and accelerate angiogenesis and tumor growth; on the other hand, exosomes can suppress tumor cell invasion, inhibit fibrosis of the heart, liver and kidney, and improve myocardial infarction by inhibiting EMT. Exosomes modulate EMT-related signaling pathways by carrying EMT-related proteins or miRNA to exert their bi-directional regulatory effects.
