Co-occurrence of t(8;21)(q22;q22) and t(9;22)(q34;q11) in a case with chronic myelogenous leukemia.
10.3760/cma.j.issn.1003-9406.2019.03.015
- VernacularTitle:伴t(8;21) (q22;q22)和t(9;22) (q34;q11)的慢性粒细胞白血病一例
- Author:
Jinying GONG
1
;
Jianqiang LI
;
Yi GAI
;
Xin TIAN
;
Xiaofang FENG
;
Yani LIN
;
Enbin LIU
;
Kun RU
Author Information
1. Department of Pathology, Institute of Hematology and Blood Diseases Hospital, Chinese Academy of Medical Science and Peking Union Medical College, Tianjin 300020, China. ru kun@ihcams.ac.cn.
- Publication Type:Journal Article
- MeSH:
Chromosome Aberrations;
Chromosomes, Human;
Fusion Proteins, bcr-abl;
Humans;
In Situ Hybridization, Fluorescence;
Leukemia, Myelogenous, Chronic, BCR-ABL Positive;
genetics;
Translocation, Genetic
- From:
Chinese Journal of Medical Genetics
2019;36(3):253-256
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVE:To delineate laboratory and clinical characteristics of a case with chronic myelogenous leukemia (CML) and co-occurrence of t(9;22)(q34;q11) and t(8;21)(q22;q22).
METHODS:The patient was subjected to cytogenetic, molecular, morphological and immunophenotypic analyses.
RESULTS:Cytogenetic analysis revealed presence of t(8;21)(q22;q22) in addition to t(9;22)(q34;q11) in the patient. Chimeric BCR/ABL and AML1/ETO genes were detected by fluorescence in situ hybridization (FISH). Transcripts of BCR/ABL210 and AML1/ETO fusion genes were detected by relative quantity PCR. Morphological study suggested that the patient was at the chronic phase of CML. No significant immunophenotypic abnormality was detected by flow cytometry.
CONCLUSION:Co-occurrence of t(8;21)(q22;q22) and t(9;22)(q34;q11) is rare in CML. Only 5 similar cases have been described previously. This case suggested that chromosomal alterations may precede morphological, flow cytometric and clinical changes and accelerate progression of the disease.
