The Hidden Culprit: A Case of Repeated Anaphylaxis to Cremophor.
10.4168/aair.2016.8.2.174
- Author:
Young Nam KIM
1
;
Jun Young KIM
;
Ji Won KIM
;
Jin Hae KIM
;
Hye In KIM
;
Sehyo YUNE
;
Dong Chull CHOI
;
Byung Jae LEE
Author Information
1. Department of Medicine, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Korea. leebj@skku.edu
- Publication Type:Case Report
- Keywords:
Anaphylaxis;
paclitaxel;
multivitamin;
cremophor;
hypersensitivity
- MeSH:
Anaphylaxis*;
Drug Therapy;
Humans;
Hypersensitivity;
Lung Neoplasms;
Paclitaxel;
Skin
- From:Allergy, Asthma & Immunology Research
2016;8(2):174-177
- CountryRepublic of Korea
- Language:English
-
Abstract:
Drug-induced anaphylaxis is a big pitfall in patients receiving antineoplastic chemotherapy. We report a case of lung cancer patient who experienced two near-fatal anaphylactic reactions that resulted from paclitaxel and multivitamin, seperately. Recurrent severe reactions to different agents led to further investigation to which material the patient was hypersensitive. The skin prick test revealed sensitization to cremophor, which is a commonly used emulsifying agent. This case emphasizes the importance of correctly identifying the culprit drug of anaphylaxis to avoid potentially fatal reaction.
