Correlation of DEFB1 polymorphisms with chronic periodontitis in Henan Han population.
10.3760/cma.j.issn.1003-9406.2019.04.020
- Author:
Xin MA
1
;
Hao LI
2
;
Haiyan CHOU
2
Author Information
1. Department of Stomatology, Henan Provincial People's Hospital, Zhengzhou, Henan, 450003, China. Email: zzhnsyymx@126.com.
2. Department of Plastic Surgery, Henan Provincial People's Hospital, Zhengzhou, Henan, 450003, China.
- Publication Type:Journal Article
- MeSH:
Alleles;
Case-Control Studies;
Chronic Periodontitis;
genetics;
Gene Frequency;
Genetic Predisposition to Disease;
Genotype;
Humans;
Polymorphism, Genetic;
beta-Defensins;
genetics
- From:
Chinese Journal of Medical Genetics
2019;36(4):371-375
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVE:To investigate the association between the polymorphisms of 5'-UTR -52G/A (rs1799946), -44C/G (rs1800972), -20G/A (rs11362) in DEFB1 gene with chronic periodontitis in Henan Han population.
METHODS:Peripheral blood genomic DNA of 436 patients with chronic periodontitis and 440 healthy controls were extracted and subjected to PCR-Sanger sequencing to determine the genotypes of DEFB1 5'-UTR -52G/A (rs1799946), -44C/G (rs1800972) and -20G/A (rs11362). The distribution of genotypes, allele frequencies and risk factors were analyzed by chi-square test and Logistic regression.
RESULTS:There was no significant difference between healthy controls and chronic periodontitis in the genotype of -52G/A PCR- (rs1799946) and -20G/A (rs11362) (P> 0.05). While a significant difference was found between healthy controls and chronic periodontitis in -44C/G (rs1800972), the CC and CG genotype rate in the two groups were 64.5%, 82.1% and 28.2%, 14.4% respectively. One-way logistic analysis showed that the CG, GG genotype and allele G might be a protective factor.
CONCLUSION:The DEFB1 -44C/G (rs1800972) is associated with chronic periodontitis in Henan Han population, and the -44CG, GG genotype and G allele may be the protective factors of chronic periodontitis in Henan Han population.
