Association of EphA2 gene polymorphisms with susceptibility to age-related cataract among ethnic Han Chinese from Hubei.
10.3760/cma.j.issn.1003-9406.2019.04.022
- Author:
Yuchan HUANG
1
;
Qingchun LI
1
;
Feng WU
2
Author Information
1. Department of ENT and Ophthalmology, Hubei Science and Technology College, Xianning, Hubei 437100, China. Email: 2165571052@qq.com.
2. Department of ENT, Head and Neck Surgery, the Second Affiliated Hospital of Hubei College of Science and Technology, Xianning, Hubei 437100, China.
- Publication Type:Journal Article
- MeSH:
Asian Continental Ancestry Group;
Cataract;
genetics;
China;
Gene Frequency;
Genetic Predisposition to Disease;
Genotype;
Haplotypes;
Humans;
Polymorphism, Genetic
- From:
Chinese Journal of Medical Genetics
2019;36(4):380-383
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVE:To assess the association of Eph-receptor tyrosinekinase-type A2 (EphA2) gene polymorphisms with susceptibility to age-related cataract (ARC) among ethnic Han Chinese from Hubei Province.
METHODS:280 patients with cortical ARC and 200 healthy controls were recruited. Polymorphisms at four loci (rs3768293, rs3754334, rs477558 and rs7548209) of the EphA2 gene were detected by PCR-restriction fragment length polymorphism (PCR-RELP) assay. Allelic and genotypic frequencies of the two groups were compared.
RESULTS:Compared with the control group, the AA genotype of rs3768293 locus was more common, while the AC genotype was much rarer (P< 0.05). No significant difference was found in allelic and genotypic frequencies of rs3754334 locus between the two groups (P> 0.05). The AA genotype of the rs477558 locus was more common in the patient group, while the AG genotype was much rarer (P< 0.05). The genotype GG of the rs7548209 locus was more common in the patient group, while the CG genotype was rarer (P< 0.05), though no significant difference in allelic or haplotypic frequencies between the two groups (P> 0.05).
CONCLUSION:Polymorphisms of rs477558, rs7548209 and rs3768293 loci of the EphA2 gene are associated with susceptibility to ARC among ethnic Han Chinese from Hubei province.
