Analysis of genetic polymorphisms of 21 autosomal short tandem repeat loci among Han Chinese from Quanzhou.
10.3760/cma.j.issn.1003-9406.2019.04.023
- VernacularTitle:泉州汉族21个常染色体短串联重复基因座的多态性研究
- Author:
Ruiya SONG
1
;
Bin PEI
2
;
Peng RAN
2
;
Xiuyu SONG
2
Author Information
1. The First Affiliated Hospital of Fujian Medical University, Fuzhou, Fujian 350004, China. Email: songxyxm@126.com.
2. Zhengdao Judicial Authentication, Xiamen Blood Center, Xiamen, Fujian 361004, China.
- Publication Type:Journal Article
- MeSH:
Asian Continental Ancestry Group;
China;
Gene Frequency;
Genetics, Population;
Humans;
Microsatellite Repeats;
Polymorphism, Genetic
- From:
Chinese Journal of Medical Genetics
2019;36(4):384-387
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVE:To analyze genetic polymorphisms of 21 autosomal short tandem repeat (STR) loci from Quanzhou Han Chinese groups using a GlobalFiler kit, and to assess its value for forensic practice.
METHODS:For 402 unrelated Han individuals, allelic frequencies of 21 autosomal STR loci were determined by using the GlobalFiler kit. Genetic parameters of the 21 STR loci were calculated.
RESULTS:No deviation from Hardy-Weinberg equilibrium was observed for the 21 loci. Most of the loci were highly polymorphic. Observed heterozygosity has ranged from 0.637 to 0.945, power of discrimination has ranged from 0.801 to 0.991, polymorphism information content has ranged from 0.570 to 0.940, power of exclusion was between 0.337 to 0.888, and match probability was between 0.009 to 0.199.
CONCLUSION:GlobalFiler kit has a high value for personal identification and paternity testing for Han Chinese from Quanzhou.
