Association of polymorphisms of miR-146a rs2910164 locus with clinical features of rheumatoid arthritis.
10.3760/cma.j.issn.1003-9406.2019.05.023
- Author:
Qiuxia HU
1
;
Bo LI
;
Ruonan SHE
;
Ximei WU
;
Jinhui TAN
;
Jianyun HU
;
Qunfang TANG
Author Information
1. Department of Rheumatology, People's Hospital of Longhua District of Shenzhen, Shenzhen, Guangdong 518109, China. Email: friendlybo@163.com.
- Publication Type:Journal Article
- MeSH:
Arthritis, Rheumatoid;
genetics;
Case-Control Studies;
Genetic Predisposition to Disease;
Genotype;
Humans;
MicroRNAs;
genetics;
Polymorphism, Single Nucleotide
- From:
Chinese Journal of Medical Genetics
2019;36(5):505-507
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVE:To assess the association of single nucleotide polymorphisms (SNPs) of microRNA-146a (miR-146a) with clinical features of rheumatoid arthritis (RA).
METHODS:In 126 patients with RA and 102 matched healthy controls, SNPs of miR-146a rs2910164 locus were determined with a high-resolution melting method. The association of such polymorphisms with disease activity score in 28 joints (DAS28) and clinical features of RA was assessed.
RESULTS:The distribution of SNPs of miR-146a rs2910164 among RA patients did not differ from that of the control group. No significant association was found between miR-146a rs2910164 polymorphism with DAS28. However, RA patients with a GG genotype had a greater chance to develop extra-articular manifestations (P<0.01).
CONCLUSION:Polymorphisms of miR-146a rs2910164 locus is not an independent risk factor for RA, though its GG genotype may be associated with extra-articular manifestations of RA.
