Association of STK39 gene polymorphism with response to hydrochlorothiazide among ethnic Han Chinese with essential hypertension.
10.3760/cma.j.issn.1003-9406.2019.06.028
- Author:
Wenjing HOU
1
;
Min LIU
2
;
Shuhua YU
2
;
Xiaofei WANG
1
;
Hongyang DU
2
;
Lijuan ZHOU
1
;
Wei CAO
1
Author Information
1. Translational Medicine Center, Zhengzhou Central Hospital Affiliated to Zhengzhou University, Zhengzhou, Henan 450007, China. Email: caoweiyu@hotmail.com.
2. Department of Hypertension, Zhengzhou Central Hospital Affiliated to Zhengzhou University, Zhengzhou, Henan 450007, China.
- Publication Type:Journal Article
- MeSH:
Asian Continental Ancestry Group;
Essential Hypertension;
Genotype;
Humans;
Hydrochlorothiazide;
Polymorphism, Single Nucleotide;
Protein-Serine-Threonine Kinases;
genetics
- From:
Chinese Journal of Medical Genetics
2019;36(6):639-644
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVE:To assess the association of single nucleotide polymorphisms (SNPs) of STK39 gene with response to hydrochlorothiazide among ethnic Han Chinese patients with essential hypertension.
METHODS:In total 118 patients with essential hypertension were recruited. All participants had received six weeks of treatment with hydrochlorothiazide 25 mg daily. Blood pressure (BP) and heart rate (HR) were measurement every 2 weeks. Genotypes of STK39 rs3754777 and rs6749447 were determined using a SNaPshot technique.
RESULTS:A significant difference was found in ΔSBP between individuals with rs3754777 CC, CT and TT and those with rs3754777 CC and CT-TT (P<0.05). A significant difference was also detected in ΔDBP between those with rs3754777 CC and CT-TT (P<0.05). No significant difference was found in ΔSBP and ΔDBP between individuals with STK39 rs6749447 GG, GT and TT (all P>0.05). Relative risk analysis showed that STK39 rs3754777 was significantly associated with BP response to hydrochlorothiazide (OR=0.416, 95%CI=0.189-0.918, P<0.05).
CONCLUSION:Polymorphisms of STK39 rs3754777 may be associated with BP response to hydrochlorothiazide among ethnic Han Chinese with essential hypertension.
