Symptomatic Profiles of 173 Chinese Patients with Essential Thrombocythemia.
10.19746/j.cnki.issn.1009-2137.2019.02.034
- Author:
Ting PAN
1
;
Xiao-Fan LIU
1
;
Wei LIU
1
;
Yue-Ting HUANG
1
;
Rong-Feng FU
1
;
Wen-Jing GU
1
;
Huan DONG
1
;
Yu-Chen GAO
1
;
Ren-Chi YANG
1
;
Lei ZHANG
2
Author Information
1. State Key Laboratory of Experimental Hematology, Key Laboratory of Gene Therapy for Blood Disease, Institute of Hematology and Blood Disease Hospital, Chinese Academy of Medical Sciences & Peking Union Medical College, Tianjin, 300020, China.
2. State Key Laboratory of Experimental Hematology, Key Laboratory of Gene Therapy for Blood Disease, Institute of Hematology and Blood Disease Hospital, Chinese Academy of Medical Sciences & Peking Union Medical College, Tianjin, 300020, China,E-mail: zhanglei1@ihcams.ac.cn.
- Publication Type:Journal Article
- MeSH:
Asian Continental Ancestry Group;
Calreticulin;
Female;
Humans;
Hydroxyurea;
Janus Kinase 2;
Mutation;
Thrombocythemia, Essential
- From:
Journal of Experimental Hematology
2019;27(2):520-526
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVE:To explore the symptomatic burden of patients with essential thrombocythemia (ET) and its relation with clinical characteristics including the mutation status, therapeutic protocols and sex.
METHODS:Total of 173 Chinese ET patients were selected and grouped on the basis of disease characteristics (mutation status, therapeutic pro to- cols, and sex).
RESULTS:All the groups showed low-to-high symptom burden, with the highest in the Hu (hydroxyurea)-group (total symptom score [TSS], 14.7; range, 7.6-14.7). In the JAK2V617F-positive, Hu-treated, and female groups TSS and independent symptom scores were higher than those in the control group. The CALR-positive and IFN-α-treated groups had lower overall and individual scores as compared with groups lacking the corresponding characteristics. As the number of characteristics (JAK2V617F-positive, Hu-treated, and female) increases, the severity of symptoms gradually increased.
CONCLUSION:The different characteristics have various effects on symptom burden in ET patients. The accumulation of certain characteristics will lead to more severe symptom burden, thus the patient＇s symptom burden should be considered comprehensively when making up the treatment schemes and prognosis.
