Clinical Characteristics and Prognosis of 84 Elderly Patients with Acute Myeloid Leukemia.
10.19746/j.cnki.issn.1009-2137.2019.03.009
- Author:
Wei WAN
1
;
Jing WANG
1
;
Fei DONG
1
;
Wei ZHAO
1
;
Lei TIAN
1
;
Kai HU
1
;
Qi-Hui LI
1
;
Ping YANG
1
;
Fang BAO
1
;
Hong-Mei JING
2
Author Information
1. Department of Hematology, The Third Hospital of Peking University, Beijing 100191, China.
2. Department of Hematology, The Third Hospital of Peking University, Beijing 100191, China,E-mail: hongmei_jing@163.com.
- Publication Type:Journal Article
- MeSH:
Aged;
Aged, 80 and over;
China;
Female;
Humans;
Induction Chemotherapy;
Leukemia, Myeloid, Acute;
Male;
Middle Aged;
Prognosis;
Remission Induction;
Retrospective Studies
- From:
Journal of Experimental Hematology
2019;27(3):692-701
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVE:To explore the prognostic factors of elderly AML patients, as well as the application and prognostic value of comprehensive geriatric assessment（CGA） in elderly AML patients in China, so as to determine a suitable comprehensive assessment method that can predict survival and guide treatment of patients in Chinese people.
METHODS:Retrospective analysis was performed on the medical records of 84 AML patients aged over 60 years old, and diagnosed in our department from October 2007 to December 2017, and the clinical, pathological and comprehensive evaluation of related prognostic factors was analyzed.
RESULTS:The median age of all patients was 70 (60-91) years old, ratio of male to female was 1.9∶1 (55∶29) , the median OS time was 9 (1-125) months, 1 year OS rate was 35.3%, and 5 year OS rate was 12.6%. The age grouping, remission of induction chemotherapy, whether refractory/relapse, WBC count grouping at initial diagnosis, levels of lactate dehydrogenase and creatinine were risk factors for OS. Remission of induction chemotherapy, whether refractory/relapse, WBC count grouping and co-infections at initial diagnosis, levels of lactate dehydrogenase, and ECOG score were the risk factors for DFS. In the assessment of comorbidities, the two score classifications of charlson comorbidity index(CCI) were the risk factor of OS, however,whose effects for DFS were not statistically different. The effects of 3 score classifications of hemaotopoietic cell transplantation comorbidity index (HCT-CI), 4 score classifications of comulative illness kating scale for geriatrics (CIRS-G) and 3 score classifications of CIRS-G on OS and DFS were not statistically different. The impact of the ACA index on OS and DFS was statistically significant in elderly patients. All indexes related with patients self factors and disease-related factors were no independent prognostic factors for OS and DFS, so the judgment of prognosis needs to be comprehensively evaluated.
CONCLUSION:The prognosis and treatment selection of elderly AML patients should be combined with traditional clinical and pathological prognostic factors as well as comprehensive assessment of the elderly patients.
