Research progress of Adenosine 5'-monophosphate-activated protein kinase in the regulation of glycolipid metabolism.

Fanming Liu; Qi Wang; Yuzhen Qian; Yejun Zhang; Bingqiang Zhang; Hongyan LI; Wei Zou

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Research progress of Adenosine 5'-monophosphate-activated protein kinase in the regulation of glycolipid metabolism.

Author: Fanming LIU ¹ ; Qi WANG ¹ ; Yuzhen QIAN ¹ ; Yejun ZHANG ¹ ; Bingqiang ZHANG ² ; Hongyan LI ¹ ; Wei ZOU ¹
Author Information

1. College of Life Sciences, Liaoning Normal University, Dalian 116081, Liaoning, China.
2. Key Laboratory of Cell Transplantation, Ministry of Health, Qingdao 266000, Shandong, China.
Publication Type:Journal Article
Keywords: AMP-activated protein kinase; diabetes; glucose metabolism; lipid metabolism
MeSH: AMP-Activated Protein Kinases; Adenosine; Adenosine Monophosphate; Energy Metabolism; Enzyme Activation; Glycolipids; Humans
From: Chinese Journal of Biotechnology 2019;35(6):1021-1028
CountryChina
Language:Chinese
Abstract: Adenosine 5'-monophosphate-activated protein activated protein kinase (AMPK), a heterotrimeric complex, is an important kinase to regulate glycolipid metabolism and energy balance involved in a variety physiological processes in human body. Many research indicated that the function and activity of AMPK were closely related to inflammation, diabetes and cancers. Recent reports show that inhibition of metformin (a first-line drug) on hepatic glucose in patients with hyperglycemia is associated with AMPK pathway, suggesting that targeting AMPK may be one of the effective strategies for the prevention and treatment of a variety of chronic diseases. Here, we review research progress on the structure, activation and regulation of AMPK in glycolipid metabolism to provide an insight into the basic and clinical research of diabetes therapy.