Recent advances in enzymatic production of alpha-keto acids.

Author: Quan ZHANG ¹ ; Wei SONG ¹ ; Can ZHANG ¹ ; Shanshan PEI ¹ ; Xiulai CHEN ¹ ; Jia LIU ¹ ; Qiuling LUO ¹ ; Liming LIU ¹
Author Information

1. State Key Laboratory of Food Science and Technology, Jiangnan University, Wuxi 214122, Jiangsu, China.
Publication Type:Journal Article
Keywords: enzymatic conversion; protein engineering; α-keto acids
MeSH: Keto Acids; metabolism
From: Chinese Journal of Biotechnology 2019;35(7):1193-1205
CountryChina
Language:Chinese
Abstract: Alpha-keto acid is a bifunctional organic compound containing both carboxyl and ketone groups, and widely applied in the industries of food, pharmaceutical and cosmetics. Based on the demand of eco-friendly process, safety and sustainable development, production of α-keto acids by enzymatic conversion technology has been paid more and more attention. In this article, we review the status of α-keto acids biosynthesis from three aspects: enzymatic screening, enzymatic modification and optimization of enzymatic conversion conditions. Meanwhile, we also indicate future research directions for further improving α-keto acids production.