Production and application of 3-phosphoadenosine-5- phosphosulfate.

Author: Zhengxiong ZHOU ¹ ; Guocheng DU ¹ ; Zhen KANG ¹
Author Information

1. Key Laboratory of Industrial Biotechnology, Ministry of Education, Jiangnan University, Wuxi 214122, Jiangsu, China.
Publication Type:Journal Article
Keywords: 3-phosphoadenosine-5-phosphosulfate; biosynthesis; chondroitin sulfate; glucosinolate; heparin; oxamniquine; sulfate group donor; sulfation
MeSH: Cell Differentiation; Chondroitin Sulfates; Phosphoadenosine Phosphosulfate; metabolism; Sulfates
From: Chinese Journal of Biotechnology 2019;35(7):1222-1233
CountryChina
Language:Chinese
Abstract: Sulfated compounds are widely present in cytoplasm, on cell surface, and in extracellular matrix. These compounds play important roles in cell development, differentiation, immune response, detoxication, and cell signal transduction. 3-Phosphoadenosine-5-phosphosulfate (PAPS) is the universal sulfate group donor for the biosynthesis of sulfated compounds. Up to now, the synthesis of PAPS is still too expensive for industrial applications. This review focuses on the recent progress of PAPS production and summaries the application of PAPS, particularly in the production of glucosinolate, heparin, condroitin sulfate, and oxamniquine production.