Gene knockout technology and its application in the study of the relationship between mitochondrial dynamics and insulin resistance.

Author: Jia XU ¹ ; Yueqi GUAN ¹ ; Zhiyi YU ¹ ; Chengshuai ZHANG ² ; Fengying GUAN ¹ ; Fen LIU ¹
Author Information

1. College of Basic Medical Sciences, Jilin University, Changchun 130021, Jilin, China.
2. College of Clinical Sciences, Jilin University, Changchun 130021, Jilin, China.
Publication Type:Journal Article
Keywords: gene knockout technology; insulin resistance; mitochondrial dynamics
MeSH: Animals; Gene Knockout Techniques; Insulin Resistance; Mice; Mitochondria; Mitochondrial Dynamics; Mitochondrial Proteins
From: Chinese Journal of Biotechnology 2019;35(8):1382-1390
CountryChina
Language:Chinese
Abstract: Mitochondrial dynamics, the processes of mitochondrial fusion and fission maintain homeostasis, are precisely regulated by fusion/fission-related proteins, and play an important physiological role in mitochondrial metabolism, quality and function. The aberrant changes of these proteins can trigger mitochondrial dynamics imbalance, which cause mitochondrial dysfunctions and result various disease states. This article focuses on gene knockout technology, and reviews the role and application progress of genes encoding for fusion and fission knockout mice in insulin resistance researches, in order to lay a foundation for future studies on signal transduction mechanism of mitochondrial dynamics imbalance in insulin resistance.