Research progress in melanogenesis signaling pathway.

Author: Meijuan ZHAO ¹ ; Jingjing HU ¹ ; Hui NI ¹ ; Zedong JIANG ¹ ; Li WANG ¹
Author Information

1. College of Food and Biological Engineering, Jimei University, Xiamen 361021, Fujian, China.
Publication Type:Journal Article
Keywords: melanogenesis; microphthalmia-associated transcription factor; signal pathway
MeSH: Cell Differentiation; Melanins; Melanocytes; Microphthalmia-Associated Transcription Factor; Signal Transduction
From: Chinese Journal of Biotechnology 2019;35(9):1633-1642
CountryChina
Language:Chinese
Abstract: Melanogenesis is a biosynthetic pathway to produce melanin pigment in melanocyte, involving a series of intricate enzymatic and chemical catalyzed reactions. Melanogenesis involves five signaling pathways that converge on microphthalmia-associated transcription factor. In addition, many cytokines, involved in the regulation of melanogenesis, play an important role in the development, proliferation, differentiation and migration of melanocytes. Polyoxometalate can be used as a potential inhibitor of melanin production. Hence, this paper reviews the signaling pathways of melanogenesis and their regulatory mechanism, to apply polyoxometalates in the melanin production pathway, and briefly introduces the regulatory factors of related pathways.