Structure-function relationships of industrial enzymes.
- Author:
Kun ZHANG
1
;
Ge QU
1
;
Weidong LIU
1
;
Zhoutong SUN
1
Author Information
- Publication Type:Journal Article
- Keywords: biocatalysis; industrial enzymes; structural flexibility; structure-function
- MeSH: Biocatalysis; Biotechnology; Enzymes; chemistry; genetics; metabolism; Metabolic Engineering; Protein Engineering; Structure-Activity Relationship
- From: Chinese Journal of Biotechnology 2019;35(10):1806-1818
- CountryChina
- Language:Chinese
- Abstract: Industrial enzymes are the "chip" of modern bio-industries, supporting tens- and hundreds-fold of downstream industries development. Elucidating the relationships between enzyme structures and functions is fundamental for industrial applications. Recently, with the advanced developments of protein crystallization and computational simulation technologies, the structure-function relationships have been extensively studied, making the rational design and de novo design become possible. This paper reviews the progress of structure-function relationships of industrial enzymes and applications, and address future developments.
