Genomics approaches decode natural products synthesis.
- Author:
Haotian CHI
1
;
Shi CHEN
1
Author Information
- Publication Type:Journal Article
- Keywords: biological chassis; genome mining; genomics; natural products
- MeSH: Animals; Biological Products; metabolism; Biosynthetic Pathways; genetics; Genome; genetics; Genomics; Multigene Family; genetics
- From: Chinese Journal of Biotechnology 2019;35(10):1889-1900
- CountryChina
- Language:Chinese
- Abstract: Novel natural products have always been the most important sources for discovery of new drugs. Since the end of the 20th century, advances in genomics technology have contributed to decode and analyze numerous genomes, revealing remarkable potential for production of new natural products in organisms. However, this potential is hampered by laboratory culture conditions. Therefore, the integration of all these new advances is necessary to unveil these treasures, addressing the rise in resistance to antibiotics. In this review, we discuss the strategies of genome mining, inducing the expression of silent biosynthetic gene clusters and construction of biological chassis.
