Application of metabolic network model to analyze intracellular metabolism of industrial microorganisms.

Author: Chao YE ¹ ; Nan XU ² ; Xiulai CHEN ¹ ; Liming LIU ¹
Author Information

1. State Key Laboratory of Food Science and Technology, Jiangnan University, Wuxi 214122, Jiangsu, China.
2. College of Bioscience and Biotechnology, Yangzhou University, Yangzhou 225009, Jiangsu, China.
Publication Type:Journal Article
Keywords: genome-scale metabolic model; intracellular metabolic activity of microorganisms; production performance; systems biology
MeSH: Industrial Microbiology; Metabolic Engineering; Metabolic Networks and Pathways; genetics; Models, Biological; Systems Biology
From: Chinese Journal of Biotechnology 2019;35(10):1901-1913
CountryChina
Language:Chinese
Abstract: To quickly and efficiently understand the intracellular metabolic characteristics of industrial microorganisms, and to find potential metabolic engineering targets, genome-scale metabolic network models (GSMMs) as a systems biology tool, are attracting more and more attention. We review here the 20-year history of metabolic network model, analyze the research status and development of GSMMs, summarize the methods for model construction and analysis, and emphasize the applications of metabolic network model for analyzing intracellular metabolic activity of microorganisms from cellular phenotypes, and metabolic engineering. Furthermore, we indicate future development trend of metabolic network model.