Simulation of industrial fermentation: current status and future perspectives.

Author: Demao LI ¹ ; Wuxi CHEN ¹ ; Wei GUO ¹ ; Chaofeng LI ¹
Author Information

1. Tianjin Key Laboratory for Industrial Biosystems and Bioprocessing Engineering, Tianjin Institute of Industrial Biotechnology, Chinese Academy of Sciences, Tianjin 300308, China.
Publication Type:Journal Article
Keywords: empirical model; fermentation; hybrid model; industry biotechnology; mechanistic model; modeling and simulation
MeSH: Biotechnology; Fermentation; Industrial Microbiology; Models, Biological
From: Chinese Journal of Biotechnology 2019;35(10):1974-1985
CountryChina
Language:Chinese
Abstract: Industrial fermentation is the basic operation unit of industrial biotechnology in large-scale production. Mathematical simulation of microbial cells and their reactors will help deepen the understanding of microorganisms and fermentation processes, and will also provide solutions for the construction of new synthetic organisms. In this paper, the characteristics of industrial fermentation system, the development of mathematical simulation, the classification, characteristics and functions of mathematical models are described in depth, and the development trend of whole fermentation system simulation is prospected.