Fermentation optimization based on cell self-adaptation to environmental stress - a review.

Author: Jian DING ¹ ; Hongzhen LUO ² ; Zhongping SHI ¹
Author Information

1. School of Biotechnology, Jiangnan University, Wuxi 214122, Jiangsu, China.
2. School of Life Science and Food Engineering, Huaiyin Institute of Technology, Huai'an 223003, Jiangsu, China.
Publication Type:Journal Article
Keywords: butanol fermentation; cell self-adaption; environmental variations; fermentation optimization; heterologous proteins production
MeSH: Adaptation, Physiological; Butanols; metabolism; Environment; Fermentation; Pichia; cytology; metabolism
From: Chinese Journal of Biotechnology 2019;35(10):1986-2002
CountryChina
Language:Chinese
Abstract: In industrial fermentation processes, bacteria have to adapt environmental stresses. Sometimes, such a self-adaption does not work and will cause fermentation failures, although such adaptation also can generate unexpected positive effects with improved fermentation performance. Our review introduces cell self-adaption to environmental variations or stress, process optimization based on such self-adaptions, with heterologous proteins production by Pichia pastoris and butanol fermentation as examples. Our review can sever as reference for fermentation optimization based on cell self-adaption.