Advances in multi-scale analysis and regulation for fermentation process.

Yanfeng Liu; Xueliang LI; Xiaolong Zhang; Xianhao XU; Long Liu; Guocheng DU

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Advances in multi-scale analysis and regulation for fermentation process.

Author: Yanfeng LIU ¹ ; Xueliang LI ² ; Xiaolong ZHANG ¹ ; Xianhao XU ¹ ; Long LIU ¹ ; Guocheng DU ¹
Author Information

1. Key Laboratory of Carbohydrate Chemistry and Biotechnology, Ministry of Education, Jiangnan University, Wuxi 214122, Jiangsu, China.
2. Key Laboratory of Industrial Biotechnology, Ministry of Education, Jiangnan University, Wuxi 214122, Jiangsu, China.
Publication Type:Journal Article
Keywords: bioreactor design; characteristics of cell metabolism; co-coupling fermentation and purification; kinetic modeling
MeSH: Bioreactors; Fermentation; Industrial Microbiology; Kinetics; Metabolic Networks and Pathways
From: Chinese Journal of Biotechnology 2019;35(10):2003-2013
CountryChina
Language:Chinese
Abstract: Industrial fermentation focuses on realizing the uniform of high titer, high yield, and high productivity. Multi-scale analysis and regulation, including molecule level, cell level, and bioreactor level, facilitate global optimization and dynamic balance of fermentation process, which determine high efficiency of biosynthesis, targeted directionality of bioconversion, process robustness, and well-organized system. In this review, we summariz and discuss advances in multi-scale analysis and regulation for fermentation process focusing on the following four aspects: 1) kinetic modeling of metabolic pathways, 2) characteristic of cell metabolism, 3) co-coupling fermentation and purification, and 4) bioreactor design. Integrating multi-scale analysis of fermentation process and integrating multi-scale regulation are expected as an important strategy for realizing highly efficient fermentation by industrial microorganisms.