A new isoflavone derivative from Rosa Damascena and its antibacterial activity.
- Author:
Jing LI
1
;
Wei-Song KONG
1
;
Xin LIU
1
;
Yong-Qin GENG
1
;
Jin WANG
1
;
Yong XU
1
;
Xue-Mei LI
1
;
Guang-Yu YANG
1
;
Min ZHOU
1
;
Qiu-Fen HU
2
;
Tao LI
1
;
Ci-Qing JIANG
2
Author Information
- Publication Type:Journal Article
- Keywords: Rosa damascena; antibacterial activity; isoflavone
- MeSH: Anti-Bacterial Agents; isolation & purification; pharmacology; Isoflavones; isolation & purification; pharmacology; Methicillin-Resistant Staphylococcus aureus; drug effects; Microbial Sensitivity Tests; Phytochemicals; isolation & purification; pharmacology; Rosa; chemistry
- From: China Journal of Chinese Materia Medica 2018;43(2):332-335
- CountryChina
- Language:Chinese
- Abstract: A new isoflavone derivative was isolated from Rosa damascena by using various chromatographic techniques including silica gel, Sephadex LH-20, and preparative RP-HPLC separation. Its structure was identified as 4'-hydroxy-7-(3-hydroxypropanoyl)-6-methoxy-isoflavone using combined examinations of their UV, IR, MS, and NMR spectroscopic data. Biological activity test showed that this compound showed prominent antibacterial activity with MIC₉₀ value of (46±4) mg·L⁻¹ for methicillin resistant Staphylococcus aureus(MRSA) strain. This value is close to that of levofloxacin [with MIC₉₀ value (53±5) mg·L⁻¹].
