Incompatible mechanism of compatibility of Chinese medicines based on Qianjinzi and Gancao effect on intestinal flora/barrier system.
10.19540/j.cnki.cjcmm.20171027.021
- Author:
Wei-Wei TAO
1
;
Jin-Gao YU
1
;
Yan-Yan CHEN
1
;
Dong XIAO
1
;
Jian-Ming GUO
1
;
Pei LIU
1
;
Jin-Ao DUAN
1
Author Information
1. Jiangsu Collaborative Innovation Center of Chinese Medicinal Resources Industrialization, National and Local Collaborative Engineering Center of Chinese Medicinal Resources Industrialization and Formulae Innovative Medicine, Nanjing University of Chinese Medicine, Nanjing 210023， China.
- Publication Type:Journal Article
- Keywords:
Gancao;
Qianjinzi;
eighteen incompatible herbs;
incompatibility of traditional Chinese medicines;
intestinal bacteria
- MeSH:
Animals;
Drugs, Chinese Herbal;
pharmacology;
Gastrointestinal Microbiome;
drug effects;
Glycyrrhiza uralensis;
chemistry;
Intestinal Mucosa;
drug effects;
pathology;
Medicine, Chinese Traditional
- From:
China Journal of Chinese Materia Medica
2018;43(2):369-371
- CountryChina
- Language:Chinese
-
Abstract:
The study was based on the toxic characteristics of the compatibility between "Zaojisuiyuan" and Gancao, with intestinal tract and intestinal bacteria as subject. From the angle of intestinal barrier function, motor function, steady state of intestinal flora and metabolism genes, the toxic and side effects of the compatibility between Qianjinzi and Gancao with similar properties, bases and chemical composition and types were further explored. The results showed that the combined application of Qianjinzi and Gancao enhanced intestinal mucosa damage, and led to abnormal changes in intestinal bacteria structure and metabolic function. It improved the degradation functions of mucus and aromatic amino acids on intestinal bacteria, which may increase the risk of disease and derived from intestinal urotoxin and other toxic substances. This study considered intestinal bacteria as an important target to study the interactions of traditional Chinese medicine. The "drug-intestinal bacteria-metabolism-toxicity" was applied in the experiment. Meanwhile, it provides ideas for exploring incompatible mechanism of traditional Chinese medicines.
