Current research situation of nephrotoxicity of Chinese herbal medicine.
10.19540/j.cnki.cjcmm.2018.0009
- Author:
Xue FENG
1
;
Sai-Nan FANG
1
;
Yu-Xin GAO
2
;
Jian-Ping LIU
1
;
Wei CHEN
1
Author Information
1. Centre for Evidence-Based Chinese Medicine， Beijing University of Chinese Medicine， Beijing 100029， China.
2. Department of Sociology， Acadia University， Wolfville B4P2R6， Canada.
- Publication Type:Journal Article
- Keywords:
Tripterygium wilfordii;
nephrotoxicity;
traditional Chinese medicine
- MeSH:
Aristolochia;
toxicity;
China;
Drugs, Chinese Herbal;
toxicity;
Ephedra sinica;
toxicity;
Humans;
Kidney;
drug effects;
Tripterygium;
toxicity
- From:
China Journal of Chinese Materia Medica
2018;43(3):417-424
- CountryChina
- Language:Chinese
-
Abstract:
To provide the basis for the future research on the nephrotoxicity of Chinese herbal medicine through systematic and comprehensive summary of all the Chinese herbal medicines which may lead to nephrotoxicity. Foreign resources included PubMed and Cochrane library， and domestic research resources was China Food and Drug Administration(CDFA) Adverse Drug Reaction Monitoring Center database. The databases were searched from establishment to January 1， 2017. There was no limitation on research type. 28 English studies were found， including 97 Chinese herbs or prescriptions with the risk of nephrotoxicity. The following six Chinese herbal medicines with the risk of nephrotoxicity had a large number of studies： aristolochic acid(5 studies)， Tripterygium wilfordii(4 studies)， Erycibe obtusifolia(2 studies)， Rheum palmatum(2 studies)， Ephedra sinica(2 studies)， and Atractylodes lances(2 studies). The remaining 91 Chinese medicines were reported with risk of nephrotoxicity in only 1 study respectively. CDFA reported 16 Chinese herbal medicines with the risk of nephrotoxicity， including Ganmaoqing Pian(capsule)， Zhenju Jiangya Pian， T. wilfordii preparation， Vc-Yinqiao Pian， Chuanhuning injection， Shuanghuanglian injection， Qingkailing injection， Lianbizhi injection， herbal decoction containing Aristolochiae Radix， Guanxin Suhe Wan， Shugan Liqi Wan， Ershiwuwei Songshi Wan， herbal decoction containing Aristolochia Fangchi， herbal granules containing root of Kaempfer Dutchmanspipe， Ganmaotong(tablets)， and Longdan Xiegan Wan. Currently， in addition to aristolochic acids， the most reported Chinese herbal medicine with the risk of nephrotoxicity is T. wilfordii preparation.
