Pharmacokinetics mechanism of ABC efflux proteins-mediated seven features of compatibility.
10.19540/j.cnki.cjcmm.2018.0016
- Author:
Shen-Shen YANG
1
;
An-Li LIU
2
;
Lan-Lan SHAN
1
;
Tong-Chun ZENG
1
;
Qian ZHOU
1
;
Yu-Bo LI
1
Author Information
1. Tianjin University of Traditional Chinese Medicine, Tianjin 300193, China.
2. Pharmacy College, Ningxia Medical University， Yinchuan 750004, China.
- Publication Type:Journal Article
- Keywords:
ABC efflux transporter;
compatibility of traditional Chinese medicine;
induction;
inhibition
- MeSH:
ATP-Binding Cassette Transporters;
metabolism;
Drug Interactions;
Humans;
Medicine, Chinese Traditional;
Multidrug Resistance-Associated Proteins;
metabolism;
Plant Preparations;
pharmacology
- From:
China Journal of Chinese Materia Medica
2018;43(4):676-683
- CountryChina
- Language:Chinese
-
Abstract:
ABC efflux proteins are a kind of transporters mediating diversified endogenous and exogenous efflux protein substrates across the plasma membrane by depending on the chemical energy released by ATP hydrolysis. As a vitally important functional membrane, it is widely found in various tissues and organs. The drug changes the expressions and/or functions of the transport proteins, which will affect the disposal process of substrate drugs corresponding to transporters , and finally lead to the pharmacokinetic interactions. The efflux proteins take part in the absorption, distribution, metabolism and excretion of drugs, and mainly consist of P-glycoprotein(P-gp), multidrug resistance associated protein(MRP) and breast cancer resistance protein(BCRP). The induction effect or inhibition effect of drugs on efflux protein plays a greatly significant role in the drug interaction produced by the compatibility of traditional Chinese medicine, which may be one of the important mechanisms of the theory of seven features of compatibility. In this article, the effects of seven features of compatibility on the ABC efflux transporters were reviewed, in order to reveal the roles of efflux protein in the herb-pairs compatibility, and provide new ideas for the mechanism and rationality of herb compatibility.
