Gene Polymorphism Is not Associated with Rheumatoid Arthritis Susceptibility in the Northern Chinese Han Population: A Case-Control Study.

Xiao-ying Zhang; Yu Zuo; Chun LI; Xin TU; Hu-ji XU; Jian-ping Guo; Zhan-guo LI; Rong MU

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Gene Polymorphism Is not Associated with Rheumatoid Arthritis Susceptibility in the Northern Chinese Han Population: A Case-Control Study.

Author: Xiao-Ying ZHANG ¹ ; Yu ZUO ² ; Chun LI ¹ ; Xin TU ³ ; Hu-Ji XU ⁴ ; Jian-Ping GUO ¹ ; Zhan-Guo LI ¹ ; Rong MU ¹
Author Information

1. Department of Rheumatology and Immunology, Peking University People's Hospital and Beijing Key Laboratory for Rheumatism Mechanism and Immune Diagnosis (BZ0135), Beijing 100044, China.
2. Department of Rheumatology, China-Japan Friendship Hospital, Beijing 100029, China.
3. Key Laboratory of Molecular Biophysics of Ministry of Education, College of Life Science and Technology, Center for Human Genome Research, Cardio-X Institute, Huazhong University of Science and Technology, Wuhan, Hubei 430000, China.
4. Department of Rheumatology and Immunology, Shanghai Changzheng Hospital, Second Military Medical University, Shanghai 200003, China.
Publication Type:Journal Article
MeSH: Adult; Aged; Arthritis, Rheumatoid; genetics; Asian Continental Ancestry Group; genetics; Case-Control Studies; China; ethnology; Female; Genetic Predisposition to Disease; Genotype; Humans; Interleukin-1; genetics; Male; Middle Aged; Polymorphism, Single Nucleotide
From: Chinese Medical Journal 2018;131(2):171-179
CountryChina
Language:English
Abstract: BACKGROUND:Interleukin (IL)-37, also called IL1F7, is a natural inhibitor of inflammatory and immune responses. It is involved in the pathogenesis of rheumatoid arthritis (RA). This study aimed to investigate the role of IL1F7 gene polymorphism in RA susceptibility in a large cohort of patients.
METHODS:Five selected single-nucleotide polymorphisms in IL1F7 genes (rs2723186, rs3811046, rs4241122, rs4364030, and rs4392270) were genotyped by TaqMan Allelic Discrimination in Northern Chinese Han population. The allele and the genotype were compared between patients with RA and healthy controls. Association analyses were performed on the entire data set and on different RA subsets based on the status of the anti-cyclic citrullinated peptide antibody and the rheumatoid factor by logistic regression, adjusting for age and gender.
RESULTS:Trend associations were detected between rs2723186, rs4241122, rs4392270, and RA in Stage I (160 patients with RA; 252 healthy controls). Further validation in Stage II comprised 730 unrelated patients with RA (mean age: 54.9 ± 12.6 years; 81.6% females) and 778 unrelated healthy individuals (mean age: 53.5 ± 15.7 years; 79.5% females). No significant differences in the distributions of alleles and genotypes were observed between the case and control groups in both the entire set and the different RA subsets. Disease activity and age of RA onset were also not associated with genotype distributions.
CONCLUSION:IL1F7 gene polymorphism does not significantly influence RA susceptibility in the Northern Chinese Han population.