Analysis of animal models based on clinical symptoms of gout.
10.19540/j.cnki.cjcmm.20180625.005
- Author:
Le KANG
1
;
Ming-San MIAO
1
;
Hui-Juan LIU
1
;
Ning LI
1
Author Information
1. Henan University of Traditional Chinese Medicine, Zhengzhou 450046, China.
- Publication Type:Journal Article
- Keywords:
clinical symptoms;
gout;
gout animal model
- MeSH:
Animals;
Disease Models, Animal;
Gout;
Hyperuricemia
- From:
China Journal of Chinese Materia Medica
2018;43(22):4547-4552
- CountryChina
- Language:Chinese
-
Abstract:
According to the characteristics of gout's clinical symptoms, the common gout animal models were analyzed, and the anastomosis and application prospect of the existing gout animal models with the clinical symptoms were discussed. At present, there are three models of gout: hyperuricemia model, gouty arthritis model and gouty nephropathy model. There are many methods of gout modeling, but there is a lack of animal model replication that could reflect the characteristics of gout's clinical symptoms and reflect the etiology of gout, and there is still a gap between the clinical symptoms and the clinical symptoms. In this paper, the characteristics and modeling methods of the three animal models were summarized, and compared with the clinical symptoms and standards, the anastomosis between the existing animal models and the clinical symptoms were analyzed and discussed, and the evaluation and improvement methods of the corresponding animal models were put forward. It provides a reliable experimental method for the treatment of gout by traditional Chinese medicine.
