A new device for determination of adhesive force and its application in predicting hot-melt sticking in spray drying of traditional Chinese medicine.
10.19540/j.cnki.cjcmm.20181105.007
- Author:
You-Jie WANG
1
;
Xiao-Hong SHI
1
;
Jia-Xuan LI
1
;
Yan-Long HONG
2
;
Fei WU
1
;
Li-Jie ZHAO
1
;
Yi FENG
1
Author Information
1. Engineering Research Center of Modern Preparation Technology of Traditional Chinese Medicine under Ministry of Education, Innovation Research Institute of Traditional Chinese Medicine, Shanghai University of Traditional Chinese Medicine, Shanghai 201203, China.
2. Shanghai Innovation Center of Traditional Chinese Medicine Health Service, Shanghai University of Traditional Chinese Medicine, Shanghai 201203, China.
- Publication Type:Journal Article
- Keywords:
adhesive force;
hot-melt sticking;
physical tester;
spray drying
- MeSH:
Adhesives;
Desiccation;
Freezing;
Hot Temperature;
Medicine, Chinese Traditional
- From:
China Journal of Chinese Materia Medica
2018;43(23):4632-4638
- CountryChina
- Language:Chinese
-
Abstract:
A new device was designed to measure adhesive force and predict whether traditional Chinese medicine extracts would appear hot-melt sticking in spray drying process．Based on the physical property tester as fundamental test platform, the device was fixed with a camera, a temperature and humidity sensor probe and a set of equipment for hot air. This device could simulate the dry environment of spray dryer and analyze the variables of testing solutions' adhesiveness against drying time. To establish and validate a model of predicting hot-melt sticking in spray drying, data was collected by using data mining. The results of this study proved that the device could be used to predict the hot-melt sticking in spray drying based on the adhesive force of materials (testing solutions). In addition, the study also found that the adhesiveness of the hot-melt sticking materials gradually increased with the evaporation of water, while that of non-sticking materials first increased and then rapidly decreased.
