Identification of effective components from Naoxintong Capsules intestinal absorption liquid in inhibiting ADP-induced platelet aggregation.
10.19540/j.cnki.cjcmm.20181105.011
- Author:
Yu-Fei GUO
1
;
Ye ZHAO
1
;
Zi-Long HE
1
;
Wen-Juan FANG
1
;
Hong-Wei WU
1
;
Fang-Bo ZHANG
1
;
Hong-Jun YANG
1
Author Information
1. Institute of Chinese Materia Medica, China Academy of Chinese Medical Sciences, Beijing 100700, China.
- Publication Type:Journal Article
- Keywords:
ADP;
Naoxintong Capsules;
intestinal absorption liquid;
platelet aggregation
- MeSH:
Adenosine Diphosphate;
Capsules;
Drugs, Chinese Herbal;
Intestinal Absorption;
Platelet Aggregation
- From:
China Journal of Chinese Materia Medica
2018;43(23):4639-4644
- CountryChina
- Language:Chinese
-
Abstract:
Intestinal absorption liquid was prepared by using everted intestinal sac method; meanwhile, its recipes were decomposed or restructured. Platelet aggregation activity was examined by biochemical tests and a microplate reader. One or more kinds of Chinese medicines which displayed inhibiting activity in Naoxintong Capsules were screened through separation and combination of prescription. The results showed that Naoxintong Capsules could inhibit ADP-induced platelet aggregation. Recipe decomposition and restructuring results showed that Salviae Miltiorrhizae Radix et Rhizoma, Paeoniae Radix Rubra, Cinnamomi Ramulus and Hirudo were the main effective medicines in inhibiting platelet aggregation. Furthermore, Cinnamomi Ramulus played a vital role in inhibiting activity among those four kinds of Chinese medicines. Coumarin derived from intestinal absorption liquid of Cinnamomi Ramulus had inhibiting activity in the range of 50-200 μmol·L⁻¹, and other ingredients such as cinnamyl alcohol and cinnamaldehyde also had inhibiting activities. In conclusion, Salviae Miltiorrhizae Radix et Rhizoma, Paeoniae Radix Rubra, Cinnamomi Ramulus and Hirudo are the main components for inhibiting ADP-induced platelet aggregation, and Cinnamomi Ramulus has the most strongest inhibiting activity in Naoxintong Capsules.
