Effective components and signaling pathways of Epimedium brevicornumbased on network pharmacology.
10.19540/j.cnki.cjcmm.20180905.001
- Author:
Run-Tong ZHANG
1
;
Hai-Ning WU
2
;
Gui-Hong YU
2
;
Yuan-Li ZHOU
2
;
Xiao-Bin JIA
2
;
Liang FENG
2
Author Information
1. Key Laboratory of New Drug Delivery System of Chinese Materia Medica, Jiangsu Provincial Academy of Chinese Medicine, Nanjing 210028, China.
2. School of Chinese Medicine Pharmacy, China Pharmaceutical University, Nanjing 211198, China.
- Publication Type:Journal Article
- Keywords:
Epimedium brevicornum;
component discovery;
component-target;
network pharmacology
- MeSH:
Epimedium;
classification;
metabolism;
Estrogens;
Flavonoids;
Signal Transduction
- From:
China Journal of Chinese Materia Medica
2018;43(23):4709-4717
- CountryChina
- Language:Chinese
-
Abstract:
The aim of this paper was to find out the active components of Epimedium brevicornum using network pharmacology, and find the potential targets and mechanisms. The TCMSP database was used to screen the active ingredients, and TTD and DrugBank databases were used to predict the potential targets with the literature mining. The pathway annotation was used to enrich and analyze the active ingredients and potential targets of E. brevicornum. The results showed that E. brevicornum had34 potential target active ingredients, including 21 flavones components, such as icariin, epimedin A, epimedin B, epimedin C, Yinyanghuo A, Yinyanghuo C and so on, 2 lignans involved in (+)-cycloolivil and olivil, 3 sterols consisting of sitosterol, 24-epicampesterol and poriferast-5-en-3beta-ol. The main predicted targets included Ptgs2, NCOA6, RANK, OPG, WNT9B, PTH1R, BMPs, SMAD4A and so on. There were 88 signaling pathways involved in 10 signaling pathways which was related to inflammation, such as NF-kappa B signaling pathway, T cell receptor signaling pathway, IL-17 signaling pathway and 10 pathways which was related to cancer included breast cancer, bladder cancer, pancreatic cancer and so on, and estrogen related signaling pathways included estrogen signaling pathway. This laid the foundation for the discovery of the active components of Epimedium and the study on its mechanism of action.
