Flavonoids with PTP1B inhibition from Broussonetia papyrifera.
10.19540/j.cnki.cjcmm.2019.0002
- Author:
Yang LOU
1
;
Shi-Yun SU
2
;
Ya-Nan LI
2
;
Chun LEI
2
;
Jing-Ya LI
3
;
Ai-Jun HOU
2
Author Information
1. School of Life Sciences,Shanghai University Shanghai 200444,China.
2. School of Pharmacy,Fudan University Shanghai 201203,China.
3. Shanghai Institute of Materia Medica,Chinese Academy of Sciences Shanghai 201203,China.
- Publication Type:Journal Article
- Keywords:
Broussonetia papyrifera;
chemical constituents;
flavonoids;
protein tyrosine phosphatase 1B
- MeSH:
Broussonetia;
chemistry;
Chromatography, High Pressure Liquid;
Flavonoids;
isolation & purification;
pharmacology;
Magnetic Resonance Spectroscopy;
Phytochemicals;
isolation & purification;
pharmacology;
Protein Tyrosine Phosphatase, Non-Receptor Type 1;
antagonists & inhibitors
- From:
China Journal of Chinese Materia Medica
2019;44(1):88-94
- CountryChina
- Language:Chinese
-
Abstract:
Eleven flavonoids were isolated from the twigs of Broussonetia papyrifera by column chromatography over silica gel,ODS,MCI gel,and Sephadex LH-20,as well as RP-HPLC.Their structures were identified by spectroscopic methods including NMR,MS,UV,and IR as broupapyrin A(1),5,7,3',4'-tetrahydroxy-3-methoxy-8-geranylflavone(2),8-prenylquercetin-3-methyl ether(3),broussonol D(4),broussoflavonol B(5),uralenol(6),broussonol E(7),8-(1,1-dimethylallyl)-5'-(3-methylbut-2-enyl)-3',4',5,7-tetrahydroxyflanvonol(8),broussoflavonol E(9),4,2',4'-trihydroxychalcone(10),and butein(11).Compound 1 is a new isoprenylated flavonol.Compounds 3,6,10,and 11 were obtained from the genus Broussonetia for the first time,and 4 and 7 were firstly discovered in B.papyrifera.Compounds 1-5 and 7-9 showed significant inhibitory effects on PTP1 B with IC50 values ranging from(0.83±0.30) to(4.66±0.83) μmol·L-1.
