A new eudesmane type sesquiterpene from cultivated Clerodendranthus spicatus in Hainan.
10.19540/j.cnki.cjcmm.20181101.011
- Author:
Hui-Qin CHEN
1
;
Rong-Rong ZHANG
2
;
Wen-Li MEI
1
;
Cai-Hong CAI
1
;
Cui-Juan GAI
1
;
Xu-Dong YU
3
;
Hao-Fu DAI
1
Author Information
1. Key Laboratory of Biology and Genetic Resources of Tropical Crops,Ministry of Agriculture,Chinese Academy of Tropical Agricultural Sciences Haikou 571101,China Hainan Key Laboratory for Research and Development of Natural Products from Li Folk Medicine Haikou 571101,China.
2. Key Laboratory of Biology and Genetic Resources of Tropical Crops,Ministry of Agriculture,Chinese Academy of Tropical Agricultural Sciences Haikou 571101,China Hainan Key Laboratory for Research and Development of Natural Products from Li Folk Medicine Haikou 571101,China College of Agronomy,Hainan University Haikou 570228,China.
3. College of Agronomy,Hainan University Haikou 570228,China.
- Publication Type:Journal Article
- Keywords:
Clerodendranthus spicatus;
eudesmane type sesquiterpene;
α-glucosidase inhibitory activity
- MeSH:
China;
Glycoside Hydrolase Inhibitors;
isolation & purification;
pharmacology;
Lamiaceae;
chemistry;
Molecular Structure;
Phytochemicals;
isolation & purification;
pharmacology;
Sesquiterpenes, Eudesmane;
isolation & purification;
pharmacology
- From:
China Journal of Chinese Materia Medica
2019;44(1):95-99
- CountryChina
- Language:Chinese
-
Abstract:
Six compounds were isolated from the aerial part of cultivated Clerodendranthus spicatus in Hainan with various chromatographic techniques,and their structures were determined as:1-dehydroxy-1-oxo-rupestrinol(1),N-trans-feruloyltyramine(2),methyl 3,4-dihydroxyphenyllactate(3),caffein acid(4),methyl caffeate(5) and ethyl caffeate(6),via analysis of physicochemical properties and spectroscopic evidence.Compound 1 was a new compound,while compounds 2 and 3 were isolated from C.spicatus for the first time.Biological activity results showed that compounds 2-4 exhibited α-glucosidase inhibitory activity with different inhibition ratio.
