Systemic review of Jintiange Capsules in treatment of postmenopausal osteoporosis.
10.19540/j.cnki.cjcmm.20180709.007
- Author:
Yi-Ru ZHAO
1
;
Xu WEI
2
;
Jun-Jie JIANG
3
;
Yi-Li ZHANG
3
;
Shang-Quan WANG
2
;
Yan-Ming XIE
3
Author Information
1. Institute of Basic Research in Clinic Medicine,China Academy of Chinese Medical Sciences Beijing 100700,China Guang'anmen Hospital,China Academy of Chinese Medical Sciences Beijing 100053,China.
2. Wangjing Hospital,China Academy of Chinese Medical Sciences Beijing 100102,China.
3. Institute of Basic Research in Clinic Medicine,China Academy of Chinese Medical Sciences Beijing 100700,China.
- Publication Type:Journal Article
- Keywords:
Jintiange Capsules;
evidence;
postmenopausal osteoporosis;
randomized controlled trial;
systemic review
- MeSH:
Antineoplastic Agents;
therapeutic use;
Bone Density;
Calcium;
blood;
Capsules;
Female;
Fractures, Bone;
prevention & control;
Humans;
Male;
Osteoporosis, Postmenopausal;
drug therapy;
Quality of Life
- From:
China Journal of Chinese Materia Medica
2019;44(1):186-192
- CountryChina
- Language:Chinese
-
Abstract:
To systemically evaluate the efficacy and safety of Jintiange Capsules in the treatment of postmenopausal osteoporosis(PMOP).Seven literature databases were retrieved systematically,and two reviewers independently searched and screened studies,extracted data,and included all the randomized controlled trials on Jintiange Capsules in the treatment of PMOP.Interventions included comparison of Jintiange Capsules with placebo and routine treatment,and the studies on Jintiange Capsules combined with routine treatment versus conventional treatment were also included.The evaluation indicators of the study included at least one of the followings:fracture,quality of life,daily living ability,clinical symptoms,death,adverse events/adverse reactions,bone density,and bone metabolism indexes.The original study quality evaluation was conducted by following the Cochrane Handbook standard and statistical analysis was performed by using Rev Man 5.2.A total of 7 randomized controlled trials were included and the study quality was low.Meta-analysis showed that as compared with conventional treatment alone,Jintiange Capsules combined with conventional treatment showed more obvious effects in pain relief(MD=-0.98,95% CI[-1.55,-0.41],P=0.000 8),increasing blood calcium levels(MD=0.05,95% CI[0.02,0.09],P=0.003) and lowering serum alkaline phosphatase levels(MD=-12.92,95% CI[-24.09,-1.75],P=0.02).In addition,the Chinese patent medicine alone or in combination with conventional treatment was relatively safe.In conclusion,Jintiange Capsules has a certain effect in treating PMOP,but the quality of evidence is low.It is necessary to conduct well designed randomized controlled trials and select recognized evaluation indicators,especially the end outcomes in order to further improve the clinical evidence.
