TCM chemical biology--emerging interdiscipline of "TCM chemistry" and "biology".
10.19540/j.cnki.cjcmm.20190222.011
- Author:
Ke-Wu ZENG
1
;
Yong JIANG
1
;
Jing WANG
1
;
Min YE
1
;
Jun LI
2
;
Xiao-Ni AI
1
;
Yue-Lin SONG
2
;
Li-Wen HAN
3
;
Ke-Chun LIU
3
;
Peng-Fei TU
4
Author Information
1. State Key Laboratory of Natural and Biomimetic Drugs,School of Pharmaceutical Sciences,Peking University Beijing 100191,China.
2. Modern Research Center for Traditional Chinese Medicine,School of Chinese Materia Medica,Beijing University of Chinese Medicine Beijing 100029,China.
3. Biology Institute,Qilu University of Technology(Shandong Academy of Sciences) Ji'nan 250103,China.
4. State Key Laboratory of Natural and Biomimetic Drugs,School of Pharmaceutical Sciences,Peking University Beijing 100191,China Modern Research Center for Traditional Chinese Medicine,School of Chinese Materia Medica,Beijing University of Chinese Medicine Beijing 100029,China.
- Publication Type:Journal Article
- Keywords:
chemical biology;
traditional Chinese medicine chemical biology(TCMCB);
traditional Chinese medicine chemistry;
traditional Chinese pharmacology
- MeSH:
Biology;
Chemistry;
Interdisciplinary Research;
Medicine;
Medicine, Chinese Traditional;
Research Design
- From:
China Journal of Chinese Materia Medica
2019;44(5):849-860
- CountryChina
- Language:Chinese
-
Abstract:
Traditional Chinese medicine(TCM) is a research area with highly original innovation features,and is also a Chinese name card to the world. However,TCM owns a unique theoretical system which is quite different from western modern medicine,leading to an awkward situation of deficient modern social identity as well as poor international spread. Therefore,how to establish a research strategy in line with the characteristics of TCM itself to systematically interpret the unique scientific connotation of TCM is always a public hot topic. Based on persistent practical exploration and scientific consideration in TCM,our group firstly promoted the concept of traditional Chinese medicine chemical biology(TCM chemical biology,TCMCB). The major idea of TCMCB is to clarify the nature of TCM regulating life progress to link TCM to modern medicine by using TCM components as chemical tools. Notably,TCMCB mainly focuses on TCM target identification and TCM-guided disease molecular mechanism exploration,further to clarify the basic law of TCM mediating disease process. Finally,TCMCB-guided scientific studies can help explain TCM theory and promote the developmentof modern innovative drugs based on identified targets using TCM active components. Moreover,TCMCB is of vital importance for investigating the scientific nature of biological progress and the pattern of disease occurrence and development,indicating a key significance for modern life science and medicine. This review introduces the definition of TCMCB as well as its academic thought,research method,technology system and scientific significance,for providing new research ideas and scientific thoughts for TCM development.
