Changes of lymphatic vessel density in lung adenocarcinoma in situ, minimally invasive adenocarcinoma, and invasive adenocarcinoma and the regulatory factors.
10.12122/j.issn.1673-4254.2018.11.12
- Author:
Ping HE
1
;
Xia GU
1
;
Xin ZENG
1
;
Yongmei ZHENG
1
;
Xiaodong LIN
1
Author Information
1. Department of Pathology, First Affiliated Hospital of Guangzhou Medical University, Guangzhou 510120, China.
- Publication Type:Journal Article
- Keywords:
MT1-MMP;
VEGF-C;
lung adenocarcinoma;
lymphatic vessel density
- MeSH:
Adenocarcinoma;
chemistry;
pathology;
Adenocarcinoma of Lung;
chemistry;
pathology;
Humans;
Immunohistochemistry;
Lymphangiogenesis;
Lymphatic Vessels;
chemistry;
pathology;
Neoplasm Staging;
Prognosis;
Tumor Burden;
Vascular Endothelial Growth Factor C;
analysis
- From:
Journal of Southern Medical University
2018;38(11):1349-1353
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVE:To analyze the changes in tumor lymphatic vessel density (LVD) in patients with lung adenocarcinoma in situ (AIS), minimally invasive adenocarcinoma (MIA), and invasive adenocarcinoma (IA) and explore the regulatory factors of LVD.
METHODS:Complete clinicopathological data were collected form a total of 301 patients with lung adenocarcinoma, including 28 (9.3%) with AIS, 86 (28.6%) with MIA, and 187 (62.1%) with IA. The LVD of all the adenocarcinomas were calculated after D2-40 immunohistochemical staining, and MT1-MMP and VEGF-C expression levels were also evaluated. The differences in LVD among the groups and the correlations of tumor LVD with the expressions of MT1-MMP and VEGF-C and the clinicopathological factors were analyzed.
RESULTS:The LVD differed significantly among AIS, MIA, and IA groups (= 0.000). The LVDs was significantly correlated with the level of VEGF-C protein expression (=0.917, =0.009), tumor size (= 0.686, =0.017), lymph node metastasis (=0.739, =0.000), and clinical stage (=0.874, =0.012) of the patients.
CONCLUSIONS:Tumor lymphangiogenesis plays an important role in lung adenocarcinoma progression, and VEGF-C may promote this process.
