Advances in metabolic engineering of heterotrophic microorganisms for CO₂ fixation: a review.
- Author:
Hua BIAN
1
;
Xinxiao SUN
1
;
Qipeng YUAN
1
Author Information
- Publication Type:Journal Article
- Keywords: CO₂ fixation; Calvin cycle; electrochemistry; non-oxidative glycolysis; serine cycle
- MeSH: Carbon Cycle; Carbon Dioxide; Heterotrophic Processes; Metabolic Engineering; Metabolic Networks and Pathways
- From: Chinese Journal of Biotechnology 2019;35(2):195-203
- CountryChina
- Language:Chinese
- Abstract: Environmental protection and energy supply are our two major concerns. Greenhouse gases released from energy consumption have serious impact on the environment. CO₂ fixation can be used to convert CO₂ into fuels or chemicals. However, natural carbon-fixing organisms usually have some disadvantages such as slow growth and low carbon fixation efficiency. Enhancing or remodeling CO₂ fixation pathways in model microorganisms can realize CO₂ recycling, which can further increase fuel or chemical production and reduce greenhouse gas emission. This review describes in detail metabolic engineering of CO₂ fixation pathways to improve chemical production and sugar synthesis, elaborates the role of relevant metabolic pathways and key enzymes in CO₂ fixation, introduces the application of electro-biochemical synthesis system, shows the great potential of CO₂ fixation, and prospects the future research direction of CO₂ fixation.
